Zhao Rui, Xiang Jia, Wang Bo, Chen Lin, Tan Songwen
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410013, China.
Bioinorg Chem Appl. 2022 Jan 28;2022:2444516. doi: 10.1155/2022/2444516. eCollection 2022.
With the development of nanotechnology, noble metal nanoparticles are widely used in the treatment of cancer due to their unique optical properties, excellent biocompatibility, surface effects, and small size effects. In recent years, researchers have designed and synthesized a large number of nanomedicines that can be used for cancer treatment based on the morphology, physical and chemical properties, mechanism of action, and toxicological studies of noble metal nanoparticles. Furthermore, the integration of diagnosis and treatment, hyperthermia, cytotoxicity research, and drug delivery system based on the study of noble metal nanoparticles can be used as effective means for cancer treatment. This article focuses on the analysis of noble metal nanoparticles that are widely used in the treatment of cancer, such as gold nanoparticles, silver nanoparticles, platinum nanoparticles, and palladium nanoparticles. The various methods and mechanisms of action of noble metal nanoparticles in the treatment of cancer are objectively summarized in detail. Based on the research on the therapeutic safety and toxicity of noble metal nanoparticles, the development prospect of noble metal nanoparticles in the future clinical application is prospected.
随着纳米技术的发展,贵金属纳米粒子因其独特的光学性质、优异的生物相容性、表面效应和小尺寸效应而被广泛应用于癌症治疗。近年来,研究人员基于贵金属纳米粒子的形态、物理化学性质、作用机制和毒理学研究,设计并合成了大量可用于癌症治疗的纳米药物。此外,基于贵金属纳米粒子的研究,诊疗一体化、热疗、细胞毒性研究以及药物递送系统可作为癌症治疗的有效手段。本文重点分析了广泛应用于癌症治疗的贵金属纳米粒子,如金纳米粒子、银纳米粒子、铂纳米粒子和钯纳米粒子。详细客观地总结了贵金属纳米粒子治疗癌症的各种方法和作用机制。基于对贵金属纳米粒子治疗安全性和毒性的研究,展望了贵金属纳米粒子在未来临床应用中的发展前景。