Department of General Chemical Technology, Ivanovo State University of Chemistry and Technology, 153000 Ivanovo, Russia.
Molecules. 2022 Oct 28;27(21):7346. doi: 10.3390/molecules27217346.
Today, complexes of gold(I) and gold(III) are recognized as promising drugs for the treatment of bacterial infectious diseases and oncological diseases, respectively. It is of interest to broaden the area of potential use of gold(III) compounds to the pathogenic microorganism as well. The first step towards the development of new antibacterial drugs based on Au complexes is the study of their stability in an aqueous solution. The present contribution reports on the investigation of gold(III) complexation with five hydrazones derived from a well-known biologically active compound, pyridoxal 5'-phosphate (one of the aldehyde forms of the B vitamin). The complex formation in aqueous solutions was confirmed by mass spectrometry and fluorescent spectroscopy. The stoichiometric composition of the complexes formed and their stability constants were determined using a UV-Vis titration method. The complexes are quite stable at physiological values of pH, as the speciation diagrams show. The results of the paper are helpful for further studies of gold(III) complexes interaction with biomacromolecules.
今天，人们认为金（I）和金（III）配合物分别是治疗细菌性传染病和肿瘤疾病的有前途的药物。将金（III）化合物的潜在用途扩展到致病微生物领域是很有意义的。基于 Au 配合物开发新型抗菌药物的第一步是研究它们在水溶液中的稳定性。本研究报告了对金（III）与五种腙的配合物的研究，这些腙是由一种众所周知的生物活性化合物，即吡哆醛 5'-磷酸（B 族维生素的醛形式之一）衍生而来的。通过质谱和荧光光谱证实了在水溶液中的配合物形成。使用紫外-可见滴定法确定了形成的配合物的化学计量组成和稳定常数。如图所示，配合物在生理 pH 值下相当稳定。本文的结果有助于进一步研究金（III）配合物与生物大分子的相互作用。
