Department of Analytical Chemistry, Sciences Faculty, University of Granada, E-18071 Granada, Spain.
Departamento de Química Analítica, Escuela Politécnica Superior, Universidad de Sevilla, C/Virgen de África 7, E-41011 Seville, Spain.
Molecules. 2022 Nov 4;27(21):7569. doi: 10.3390/molecules27217569.
There is increasing scientific evidence that some pharmaceuticals are present in the marine ecosystems at concentrations that may cause adverse effects on the organisms that inhabit them. At present, there is still very little scientific literature on the (bio)accumulation of these compounds in different species, let alone on the relationship between the presence of these compounds and the adverse effects they produce. However, attempts have been made to optimize and validate analytical methods for the determination of residues of pharmaceuticals in marine biota by studying the stages of sample treatment, sample clean-up and subsequent analysis. The proposed bibliographic review includes a summary of the most commonly techniques, and its analytical features, proposed to determine pharmaceutical compounds in aquatic organisms at different levels of the trophic chain in the last 10 years.
越来越多的科学证据表明，一些药品在海洋生态系统中的浓度可能对栖息其中的生物产生不良影响。目前，关于这些化合物在不同物种中的（生物）积累，更不用说这些化合物的存在与它们产生的不良影响之间的关系，仍有很少的科学文献。然而，人们已经尝试通过研究样品处理、样品净化和随后的分析阶段来优化和验证用于测定海洋生物群中药物残留的分析方法。本文献综述包括对过去 10 年来用于在食物链的不同层次确定水生生物中药物化合物的最常用技术及其分析特点的总结。
