State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, People's Republic of China.
NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, People's Republic of China.
J Nat Prod. 2022 Nov 25;85(11):2541-2546. doi: 10.1021/acs.jnatprod.2c00353. Epub 2022 Nov 11.
Cladoxanthones A () and B (), two xanthone-derived metabolites featuring a new spiro[cyclopentane-1,2'-[3,9a]ethanoxanthene]-2,4',9',11'(4a')-tetraone skeleton, were isolated from cultures of the ascomycete fungus sp., together with the known mangrovamide J (). Their structures were elucidated primarily by NMR experiments. The absolute configurations of and were assigned by X-ray crystallography using Cu Kα radiation. Compound could be generated from the hypothetical precursors related to α-methylene ketone and dihydro-xanthone via a Diels-Alder reaction, while could be an oxidative coupling product resulting from and . Compounds and showed weakly cytotoxic effects.
克拉多酮 A()和 B()，这两种黄烷酮衍生的代谢产物具有一个新的螺[环戊烷-1,2'-[3,9a]乙烷氧杂蒽]-2,4',9',11'(4a')-四酮骨架，是从曲霉属真菌的培养物中分离得到的，同时还分离得到了已知的 mangrovamide J()。它们的结构主要通过 NMR 实验阐明。通过使用 Cu Kα 辐射的 X 射线晶体学确定了和的绝对构型。化合物可以通过 Diels-Alder 反应从与α-亚甲基酮和二氢黄烷酮相关的假想前体生成，而可以是和之间的氧化偶联产物。化合物和表现出微弱的细胞毒性作用。
