Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Hawassa University College of Medicine and Health Sciences, Hawassa, Southern Nations, Ethiopia.
Sci Rep. 2022 Nov 11;12(1):19300. doi: 10.1038/s41598-022-24034-7.
Ethiopia has made improvements in the reduction of maternal mortality; the high burden of preeclampsia remains a concern in the Sidama region. This study aimed to measure the effect of preeclampsia on adverse maternal outcomes and identify risk factors among women with preeclampsia in Sidama region. A prospective open cohort study was conducted from August 8, 2019, to October 1, 2020. We enrolled a total of 1015 the pregnant women who had preeclampsia and normotensive women at ≥ 20 weeks of gestation and followed them until 42 days after delivery. A log-binomial logistic regression model was used to estimate the incidence of adverse maternal outcomes and its risk factors. There were 276 adverse maternal outcomes observed in the preeclampsia group compared to 154 adverse maternal outcomes in the normotensive group (P < 0.001). Women with severe features of preeclampsia had a 43% (aRR = 1.43, 95% CI 1.3-1.58) higher risk for adverse maternal outcomes compared to women without severe features of preeclampsia. Women without severe features of preeclampsia had a 39% (aRR = 1.39, 95% CI 1.2-1.76) higher risk for adverse maternal outcomes compared to women in the normotensive group. More adverse maternal outcomes occurred among women with preeclampsia after controlling for confounders.
埃塞俄比亚在降低孕产妇死亡率方面取得了进展；子痫前期负担沉重仍然是西达玛地区关注的问题。本研究旨在测量子痫前期对不良产妇结局的影响，并确定西达玛地区子痫前期妇女的危险因素。一项前瞻性开放队列研究于 2019 年 8 月 8 日至 2020 年 10 月 1 日进行。我们共纳入了 1015 名患有子痫前期和血压正常的孕妇，≥20 周妊娠，并随访至产后 42 天。使用对数二项逻辑回归模型来估计不良产妇结局的发生率及其危险因素。与血压正常组的 154 例不良产妇结局相比，子痫前期组观察到 276 例不良产妇结局（P<0.001）。与无严重子痫前期特征的妇女相比，有严重子痫前期特征的妇女发生不良产妇结局的风险高 43%（ARR=1.43，95%CI 1.3-1.58）。与血压正常组相比，无严重子痫前期特征的妇女发生不良产妇结局的风险高 39%（ARR=1.39，95%CI 1.2-1.76）。在控制混杂因素后，子痫前期妇女发生更多不良产妇结局。
