Institue of Population Health Sciences, Newcastle University, Newcastle, UK.
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, LE11 3TU, UK.
Eur J Nutr. 2023 Mar;62(2):1027-1039. doi: 10.1007/s00394-022-03051-2. Epub 2022 Nov 12.
We examined the effects of collagen peptides (CP) supplementation on exercise-induced gastrointestinal (GI) stress.
In a randomized, crossover design, 20 volunteers (16 males: [Formula: see text]O, 53.4 ± 5.9 ml·kg) completed 3 trials: a non-exercise rest trial, with no supplement (REST) and then an exercise trial with CP (10 g·day) or placebo control (CON) supplements, which were consumed for 7 days prior to, and 45 min before, a 70 min run at 70-90% of [Formula: see text]O. Outcome measures included urinary lactulose and rhamnose (L/R), intestinal fatty acid binding protein (I-FABP), lipopolysaccharide (LPS), anti-LPS antibody, monocyte-chemoattractant protein-1 (MCP-1), interleukin (IL) 6 and 8, cortisol, alkaline phosphatase (ALP) (measured pre, 10 min post and 2 h post) and subjective GI symptoms.
There were no differences in heart rate, perceived exertion, thermal comfort, or core temperature during exercise in the CP and CON trials (all P > 0.05). I-FABP was higher in CP (2538 ± 1221 pg/ml) and CON (2541 ± 766 pg/ml) vs. REST 2 h post (1893 ± 1941 pg/ml) (both P < 0.05). LPS increased in CON vs. REST 2 h post (+ 71.8 pg/ml; P < 0.05). Anti-LPS antibody decreased in CON and CP vs. REST at post (both P < 0.05). There were no differences in MCP-1, IL-6, and IL-8 between the CP and CON trials (all P > 0.05), and no differences in L/R or GI symptoms between CON and CP (all P > 0.05).
Collagen peptides did not modify exercise-induced changes in inflammation, GI integrity or subjective GI symptoms but LPS was higher in CON 2 h post-exercise and thus future studies may be warranted.
研究胶原蛋白肽（CP）补充对运动引起的胃肠道（GI）应激的影响。
采用随机交叉设计，20 名志愿者（16 名男性：[公式：见文本]O，53.4±5.9ml·kg）完成了 3 项试验：非运动休息试验，无补充（REST），然后进行运动试验，补充 CP（10g·天）或安慰剂对照（CON）补充剂，在 70 分钟跑步前 7 天和 45 分钟前摄入，以 70-90%的[公式：见文本]O 进行。结果测量包括尿乳果糖和鼠李糖（L/R）、肠脂肪酸结合蛋白（I-FABP）、脂多糖（LPS）、抗 LPS 抗体、单核细胞趋化蛋白-1（MCP-1）、白细胞介素（IL）6 和 8、皮质醇、碱性磷酸酶（ALP）（在运动前、运动后 10 分钟和 2 小时测量）和主观胃肠道症状。
CP 和 CON 试验中，运动期间的心率、感知用力、热舒适度或核心温度没有差异（均 P>0.05）。CP（2538±1221pg/ml）和 CON（2541±766pg/ml）在 2 小时后高于 REST（1893±1941pg/ml）（均 P<0.05）。LPS 在 CON 中比 REST 增加 2 小时后增加（增加 71.8pg/ml；P<0.05）。CON 和 CP 中抗 LPS 抗体在 POST 中低于 REST（均 P<0.05）。CP 和 CON 试验中 MCP-1、IL-6 和 IL-8 之间无差异（均 P>0.05），CON 和 CP 之间的 L/R 或胃肠道症状无差异（均 P>0.05）。
胶原蛋白肽不会改变运动引起的炎症、胃肠道完整性或主观胃肠道症状的变化，但 CON 在运动后 2 小时的 LPS 更高，因此可能需要进一步研究。
