嘌呤能信号转导：缺血性脑卒中的潜在治疗靶点。
Purinergic signaling: a potential therapeutic target for ischemic stroke.
机构信息
Department of Neurology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, The Affiliated Hospital of University of Electronic Science and Technology of China, Chengdu, 610072, China.
出版信息
Purinergic Signal. 2023 Mar;19(1):173-183. doi: 10.1007/s11302-022-09905-y. Epub 2022 Nov 12.
Abstract
Pathogenesis of ischemic stroke is mainly characterized by thrombosis and neuroinflammation. Purinergic signaling pathway constitutes adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), and adenosine (ADO). ATP is hydrolyzed to ADP and then to AMP by extracellular nucleotidase CD39; AMP is subsequently converted to adenosine by CD73. All these nucleotides and nucleosides act on purinergic receptors protecting against thrombosis and inhibit inflammation. In addition, many physical methods have been found to play a neuroprotective role through purinergic signaling. This review mainly introduces the role and potential mechanism of purinergic signalings in the treatment of ischemic stroke, so as to provide reference for seeking new treatment methods for stroke.
摘要
缺血性脑卒中的发病机制主要表现为血栓形成和神经炎症。嘌呤能信号通路由三磷酸腺苷（ATP）、二磷酸腺苷（ADP）、一磷酸腺苷（AMP）和腺苷（ADO）组成。细胞外核苷酸酶 CD39 将 ATP 水解为 ADP，然后再水解为 AMP；随后 CD73 将 AMP 转化为腺苷。所有这些核苷酸和核苷都作用于嘌呤能受体，防止血栓形成并抑制炎症。此外，已经发现许多物理方法可以通过嘌呤能信号发挥神经保护作用。本综述主要介绍嘌呤能信号在缺血性脑卒中治疗中的作用和潜在机制，以期为寻找脑卒中的新治疗方法提供参考。
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