T Cell Biology and Development Unit, Laboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute, National Institute of Health, Bethesda, MD, USA.
Université de Nantes, CNRS, Inserm, CRCINA, Nantes, France.
Methods Mol Biol. 2023;2580:51-69. doi: 10.1007/978-1-0716-2740-2_3.
Innate lymphoid cells (ILCs) are transcriptionally and functionally similar to T cells but lack adaptive antigen receptors. They play critical roles in early defense against pathogens. In this review, we summarize recent discoveries of ILC progenitors and discuss possible mechanisms that separate ILCs from T cells. We consider mechanisms of lineage specification in early ILC development and also examine whether differences exist between adult and fetal ILC development.
先天淋巴细胞（ILCs）在转录和功能上与 T 细胞相似，但缺乏适应性抗原受体。它们在早期防御病原体方面发挥着关键作用。在这篇综述中，我们总结了 ILC 前体的最新发现，并讨论了将 ILC 与 T 细胞区分开来的可能机制。我们考虑了早期 ILC 发育中谱系特化的机制，还研究了成人和胎儿 ILC 发育之间是否存在差异。
