Pontificia Universidad Javeriana, Bogota, Colombia.
Department of Pathology, University of Texas Medical Branch, Galveston, Texas.
Am J Trop Med Hyg. 2022 Nov 14;107(6):1218-1225. doi: 10.4269/ajtmh.22-0120. Print 2022 Dec 14.
Several arboviruses have emerged or reemerged into the New World during the past several decades, causing outbreaks of significant proportion. In particular, the outbreaks of Dengue virus (DENV), Zika virus, and Chikungunya virus (CHIKV) have been explosive and unpredictable, and have led to significant adverse health effects. These viruses are considered the leading cause of acute undifferentiated febrile illnesses in Colombia. However, Venezuelan equine encephalitis virus (VEEV) is endemic in Colombia, and arboviruses such as the Mayaro virus (MAYV) and the Oropouche virus (OROV) cause febrile illnesses in neighboring countries. Yet, evidence of human exposure to MAYV and OROV in Colombia is scarce. In this study, we conducted a serosurvey study in healthy individuals from the Cauca Department in Colombia. We assessed the seroprevalence of antibodies against multiple arboviruses, including DENV serotype 2, CHIKV, VEEV, MAYV, and OROV. Based on serological analyses, we found that the overall seroprevalence for DENV serotype 2 was 30%, 1% for MAYV, 2.6% for CHIKV, 4.4% for VEEV, and 2% for OROV. This study provides evidence about the circulation of MAYV and OROV in Colombia, and suggests that they-along with VEEV and CHIKV-might be responsible for cases of acute undifferentiated febrile illnesses that remain undiagnosed in the region. The study results also highlight the need to strengthen surveillance programs to identify outbreaks caused by these and other vector-borne pathogens.
在过去几十年中，有几种虫媒病毒在新世界出现或重新出现，导致了相当比例的疫情爆发。特别是登革热病毒（DENV）、寨卡病毒和基孔肯雅热病毒（CHIKV）的爆发是爆炸性和不可预测的，导致了重大的健康影响。这些病毒被认为是哥伦比亚急性未分化发热疾病的主要原因。然而，委内瑞拉马脑炎病毒（VEEV）在哥伦比亚流行，梅萨罗病毒（MAYV）和奥罗普切病毒（OROV）等虫媒病毒在邻国引起发热疾病。然而，哥伦比亚有人类接触 MAYV 和 OROV 的证据很少。在这项研究中，我们在哥伦比亚考卡省的健康个体中进行了血清学调查研究。我们评估了针对多种虫媒病毒的抗体血清阳性率，包括 DENV 血清型 2、CHIKV、VEEV、MAYV 和 OROV。基于血清学分析，我们发现 DENV 血清型 2 的总体血清阳性率为 30%，MAYV 为 1%，CHIKV 为 2.6%，VEEV 为 4.4%，OROV 为 2%。本研究提供了关于 MAYV 和 OROV 在哥伦比亚传播的证据，并表明它们与 VEEV 和 CHIKV 一起可能是该地区未确诊的急性未分化发热疾病的原因。研究结果还强调需要加强监测计划，以识别这些和其他由媒介传播的病原体引起的疫情。
