Department of Pathology, University of Texas Medical Branch, Galveston, Texas.
School of Medicine, University of Texas Medical Branch, Galveston, Texas.
Am J Trop Med Hyg. 2021 Nov 29;106(2):607-609. doi: 10.4269/ajtmh.21-0579.
Mayaro virus (MAYV) is an alphavirus endemic to both Latin America and the Caribbean. Recent reports have questioned the ability of MAYV and its close relative, Chikungunya virus (CHIKV), to generate cross-reactive, neutralizing antibodies to one another. Since CHIKV was introduced to South America in 2013, discerning whether individuals have cross-reactive antibodies or whether they have had exposures to both viruses previously has been difficult. Using samples obtained from people infected with MAYV prior to the introduction of CHIKV in the Americas, we performed neutralizing assays and observed no discernable neutralization of CHIKV by sera from patients previously infected with MAYV. These data suggest that a positive CHIKV neutralization test cannot be attributed to prior exposure to MAYV and that previous exposure to MAYV may not be protective against a subsequent CHIKV infection.
马亚罗病毒（MAYV）是一种在拉丁美洲和加勒比地区流行的甲病毒。最近的报告质疑了马亚罗病毒及其近亲基孔肯雅病毒（CHIKV）之间产生相互交叉反应、中和抗体的能力。自 2013 年基孔肯雅病毒传入南美洲以来，要确定个体是否具有交叉反应性抗体，或者他们以前是否接触过这两种病毒，一直很困难。利用在 CHIKV 传入美洲之前从感染马亚罗病毒的人身上获得的样本，我们进行了中和测定，没有观察到先前感染马亚罗病毒的患者血清对基孔肯雅病毒有明显的中和作用。这些数据表明，阳性的基孔肯雅病毒中和试验不能归因于先前接触马亚罗病毒，而先前接触马亚罗病毒可能不能预防随后的基孔肯雅病毒感染。
