Kim Dokyeong, Shim Youn-Soo, An So-Youn, Lee Myung-Jin
Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Department of Dental Hygiene, Sunmoon University, Asan 31460, Korea.
Molecules. 2021 Mar 24;26(7):1823. doi: 10.3390/molecules26071823.
Gelatin, a natural polymer, provides excellent tissue compatibility for use in tissue rehabilitation. Bioactive glasses (BAG) offer superior capacity in stimulating a bioactive response but show high variability in uptake and solubility. To tackle these drawbacks, a combination of gelatin with BAG is proposed to form composites, which then offer a synergistic response. The cross-linked gelatin structure's mechanical properties are enhanced by the incorporation of the inorganic BAG, and the rate of BAG ionic supplementation responsible for bioactivity and regenerative potential is better controlled by a protective gelatin layer. Several studies have demonstrated the cellular benefits of these composites in different forms of functional modification such as doping with zinc or incorporation of zinc such as ions directly into the BAG matrix. This review presents a comprehensive perspective on the individual characteristics of BAG and gelatin, including the synthesis and mechanism of action. Further, adaptation of the composite into various applications for bone tissue engineering is discussed and future challenges are highlighted.
明胶是一种天然聚合物，在组织修复中具有出色的组织相容性。生物活性玻璃（BAG）在刺激生物活性反应方面具有卓越能力，但在摄取和溶解性方面表现出高度变异性。为解决这些缺点，有人提出将明胶与BAG结合以形成复合材料，从而产生协同反应。无机BAG的加入增强了交联明胶结构的机械性能，而负责生物活性和再生潜力的BAG离子补充速率则通过保护性明胶层得到更好的控制。多项研究已证明这些复合材料在不同形式的功能改性（如用锌掺杂或将锌离子直接掺入BAG基质）中对细胞有益。本综述全面介绍了BAG和明胶的各自特性，包括合成和作用机制。此外，还讨论了该复合材料在骨组织工程各种应用中的适应性，并强调了未来的挑战。
