Innih Silvanus Olu, Omage Sylvia Oghogho, Lawal Tracy Edoghogho, Omage Kingsley
Department of Anatomy, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Benin City, Nigeria.
Department of Biochemistry, Faculty of Life Sciences, University of Benin, Edo State, Nigeria.
Saudi J Biol Sci. 2022 Dec;29(12):103486. doi: 10.1016/j.sjbs.2022.103486. Epub 2022 Nov 1.
The use of to treat different diseases is popular in the practise of alternative medicine. We investigated the ability of the aqueous extract of to protect against the toxic effects of cadmium.
Thirty rats used for the experiment were treated as follows; Group 1 no cadmium or extract Group 2-10 mg/kg body weight of cadmium chloride. Group 3-10 mg/kg body weight of cadmium chloride and 200 mg/kg body weight of aqueous extract of . Group 4-10 mg/kg body weight of cadmium chloride and 400 mg/kg body weight of aqueous extract of . Group 5-10 mg/kg body weight of cadmium chloride with 800 mg/kg body weight of aqueous extract of . Group 6-10 mg/kg body weight of cadmium chloride and atorvastatin (100 mg/kg body weight).
Apart from WBC and platelets, other haematological parameters and electrolytes, urea and creatinine levels were not significantly affected by the administration of cadmium chloride along with the aqueous extract of . Treatment with the extract caused significant decreases in the hepatosomatic index, cardiosomatic index, and increase in renosomatic index of the test rats. It also resulted in significant (P < 0.05) decrease in AST level. Histological report also shows that treatment with the extract restored the normal myocardium and vascular architecture of the heart, normal portal and vascular architecture of the liver and normal glomerular and tubular architecture of the kidney, in the cadmium-intoxicated experimental rats.
protects against the toxic effects of cadmium chloride.
在替代医学实践中，使用[具体物质名称未给出]治疗不同疾病很普遍。我们研究了[具体物质名称未给出]水提取物预防镉毒性作用的能力。
用于实验的30只大鼠按以下方式处理；第1组——不给予镉或提取物；第2组——给予10mg/kg体重的氯化镉；第3组——给予10mg/kg体重的氯化镉和200mg/kg体重的[具体物质名称未给出]水提取物；第4组——给予10mg/kg体重的氯化镉和400mg/kg体重的[具体物质名称未给出]水提取物；第5组——给予10mg/kg体重的氯化镉和800mg/kg体重的[具体物质名称未给出]水提取物；第6组——给予10mg/kg体重的氯化镉和阿托伐他汀（100mg/kg体重）。
除白细胞和血小板外，其他血液学参数、电解质、尿素和肌酐水平在给予氯化镉及[具体物质名称未给出]水提取物后未受到显著影响。提取物处理导致受试大鼠的肝体指数、心体指数显著降低，肾体指数升高。它还导致AST水平显著（P<0.05）降低。组织学报告还显示，提取物处理使镉中毒实验大鼠的心脏恢复了正常心肌和血管结构、肝脏恢复了正常门静脉和血管结构、肾脏恢复了正常肾小球和肾小管结构。
[具体物质名称未给出]可预防氯化镉的毒性作用。
