Department of Reproductive Medicine, The First People's Hospital of Yunnan Province, Kunming, Yunnan, China.
Reproductive Medical Center of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China.
Am J Reprod Immunol. 2023 Mar;89(3):e13652. doi: 10.1111/aji.13652. Epub 2022 Nov 24.
In recent years, the incidence of female infertility has risen sharply, which is affected by many factors. It was recognized that female reproductive tract microbes play a role in the process of female conception. If the reproductive tract microbes could solve a certain proportion of infertility, it would certainly reduce the pain and economic burden of many patients. The objective of this study was to investigate the microbial community composition of follicular fluid in infertile patients and its potential impact on infertility.
Follicular fluid from 49 primary infertility and 52 secondary infertility patients was collected by a negative pressure needle, and the microbiota was analyzed by 16S rDNA sequencing.
It was found that Lactobacillus, especially L. crispatus, might have a positive effect on female pregnancy. Considering the presence or absence of male factors and different body mass indices, L. iners might inhibit female pregnancy. However, L. iners seemed to play a positive role in egg maturation, while Gardnerella and Cutibacterium acnes might have a negative effect on female pregnancy.
This study suggested the potential role of Lactobacillus in follicular fluid in improving female infertility and provided a theoretical basis for the future microbiological treatment of female infertility.
近年来，女性不孕症的发病率急剧上升，受多种因素影响。人们认识到女性生殖道微生物在女性受孕过程中起作用。如果生殖道微生物能解决一定比例的不孕问题，那肯定会减轻许多患者的痛苦和经济负担。本研究旨在调查不孕患者卵泡液中的微生物群落组成及其对不孕的潜在影响。
采用负压针收集 49 例原发性不孕和 52 例继发性不孕患者的卵泡液，通过 16S rDNA 测序分析微生物群。
发现乳酸杆菌，尤其是 L. crispatus，可能对女性妊娠有积极影响。考虑到是否存在男性因素和不同的体重指数，L. iners 可能会抑制女性妊娠。然而，L. iners 似乎在卵子成熟中发挥积极作用，而 Gardnerella 和 Cutibacterium acnes 可能对女性妊娠有负面影响。
本研究提示卵泡液中乳酸杆菌在改善女性不孕中的潜在作用，为未来女性不孕的微生物治疗提供了理论依据。
