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Microbiological composition of follicular fluid in patients undergoing IVF and its association with infertility.经体外受精（IVF）治疗的患者滤泡液中的微生物组成及其与不孕的关系。
Am J Reprod Immunol. 2023 Mar;89(3):e13652. doi: 10.1111/aji.13652. Epub 2022 Nov 24.
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The Role of Genital Tract Microbiome in Fertility: A Systematic Review.生殖道微生物组在生育力中的作用：系统评价。
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Bacterial Vaginosis: Effects on reproduction and its therapeutics.细菌性阴道病：对生殖的影响及其治疗。
J Gynecol Obstet Hum Reprod. 2021 Nov;50(9):102174. doi: 10.1016/j.jogoh.2021.102174. Epub 2021 Jun 2.
5
The presence of microorganisms in follicular fluid and its effect on the outcome of in vitro fertilization-embryo transfer (IVF-ET) treatment cycles.卵泡液中微生物的存在及其对体外受精-胚胎移植（IVF-ET）治疗周期结局的影响。
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The Associations of Genital Mycoplasmas with Female Infertility and Adverse Pregnancy Outcomes: a Systematic Review and Meta-analysis.解脲脲原体、人型支原体与女性不孕及不良妊娠结局的关系：系统评价和荟萃分析。
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Effect of Chlamydia trachomatis on adverse pregnancy outcomes: a meta-analysis.沙眼衣原体对不良妊娠结局的影响：一项荟萃分析。
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卵泡液中微生物存在与 IVF 结局的关系：系统评价和荟萃分析。

Associations between microbial presence in follicular fluid with IVF outcomes: a systematic review and meta-analysis.

机构信息

Center of Reproductive Medicine, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Qingxiu District, Nanning, 530021, Guangxi, China.

Key Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education; Guangxi Colleges and Universities, Key Laboratory of Biological Molecular Medicine Research, School of Basic Medical Sciences, Guangxi Medical University, Nanning, 530021, Guangxi, People's Republic of China.

出版信息

J Assist Reprod Genet. 2023 Nov;40(11):2501-2511. doi: 10.1007/s10815-023-02912-x. Epub 2023 Sep 9.

DOI:10.1007/s10815-023-02912-x
PMID:37688752
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10643413/
Abstract

PURPOSE

The aim of the study was to synthesize disparate studies to investigate potential impact of microbial presence in FF of infertile women on IVF outcomes.

METHODS

Following preliminary searches to find medical subject heading (MeSH) terms plus free terms, a systematic search was performed in the PubMed, Cochrane Library, Embase, Web of Science, and Clinicaltrials.gov databases from January 10, 2022, to July 5, 2023. Data collected for each study were analyzed using RevMan 5.4 software available on the Cochrane website.

RESULTS

After correcting for contamination from the vagina, the FFs of 289 women were detected positively by microbial culture and identification, ELISA, and IPA. The pregnancy rate of the FF-positive group was significantly lower than the FF-negative group (19.7% vs. 32.2%) and (OR: 0.57, 95% CI: 0.28-1.14, P=0.11; I=56%) while the fertilization rate was almost equal (60.0% vs. 62.0%) and (OR: 1.03, 95% CI: 0.88-1.20, P=0.72; I=0%). Evidence quality was very low.

CONCLUSIONS

The different species of microorganisms in FF of infertile women may have different effects on IVF outcomes. The Lactobacillus spp. may have a positive effect, while other microorganisms may have the opposite effect.

摘要

目的

本研究旨在综合不同研究，以探究不孕女性卵泡液（FF）中微生物存在对体外受精（IVF）结局的潜在影响。

方法

在初步搜索以找到医学主题词（MeSH）术语和自由词后，于 2022 年 1 月 10 日至 2023 年 7 月 5 日，在 PubMed、Cochrane 图书馆、Embase、Web of Science 和 ClinicalTrials.gov 数据库中进行了系统检索。使用可在 Cochrane 网站上获得的 RevMan 5.4 软件分析为每个研究收集的数据。

结果

在纠正阴道污染后，通过微生物培养和鉴定、ELISA 和 IPA 检测，289 名女性的 FF 阳性率为 19.7%（289/1465）。FF 阳性组的妊娠率显著低于 FF 阴性组（19.7% vs. 32.2%）（OR：0.57，95% CI：0.28-1.14，P=0.11；I²=56%），而受精率几乎相等（60.0% vs. 62.0%）（OR：1.03，95% CI：0.88-1.20，P=0.72；I²=0%）。证据质量为极低。

结论

不孕女性 FF 中的不同微生物物种可能对 IVF 结局有不同的影响。乳杆菌属可能有积极影响，而其他微生物可能有相反影响。