Department of Nephrology, Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, People's Republic of China.
Department of Radiotherapy, The Second Hospital of PingLiang City, Second Affiliated Hospital of Gansu Medical College, Pingliang, People's Republic of China.
Clin Genet. 2019 May;95(5):569-574. doi: 10.1111/cge.13511. Epub 2019 Feb 14.
The rapid development of precision medicine is introducing a new era of significance in medicine. However, attaining precision medicine is an ambitious goal that is bound to encounter some challenges. Here, we have put forward some difficulties or questions that should be addressed by the progress in this field. The proposed issues include the long road to precision medicine for all types of diseases as the unknown domains of the human genome hinder the development of precision medicine. The challenges in the acquisition and analysis of large amounts of omics data, including difficulties in the establishment of a library of biological samples and large-scale data analysis, as well as the challenges of informed consent and medical ethics in precision medicine, must be overcome to attain the goals of precision medicine. To date, precision medicine programs have accomplished many preliminary achievements and will help to drive a dramatic revolution in clinical practices for the medical community. Through these advances, the diagnosis and treatment of many diseases will achieve many breakthroughs. This project is just beginning and requires a great deal of time and money. Precision medicine also requires extensive collaboration. Ultimately, these difficulties can be overcome. We should realize that precision medicine is good for patients, but there is still a long way to go.
精准医学的快速发展正在为医学带来一个具有重要意义的新时代。然而，实现精准医学是一个雄心勃勃的目标，必然会遇到一些挑战。在这里，我们提出了一些该领域进展过程中应解决的困难或问题。提出的问题包括由于人类基因组的未知领域阻碍了精准医学的发展，所有类型的疾病实现精准医学的道路漫长。获取和分析大量组学数据方面存在挑战，包括生物样本库的建立和大规模数据分析方面的困难，以及精准医学中知情同意和医学伦理方面的挑战，都必须克服，才能实现精准医学的目标。迄今为止，精准医学计划已经取得了许多初步成果，并将有助于推动医学界临床实践的巨大变革。通过这些进展，许多疾病的诊断和治疗将取得许多突破。该项目才刚刚开始，需要大量的时间和资金。精准医学还需要广泛的合作。最终，这些困难都可以被克服。我们应该认识到，精准医学对患者有益，但仍有很长的路要走。
