Imran Mohammad, Gowd Vemana, Saha Puspita, Rashid Summya, Ahmad Chaudhary Anis, Mohamed Marwa Yousry A, Alawam Abdullah S, Khan Rehan
Chemical Biology Unit, Institute of Nano Science and Technology, Knowledge, City, Sector-81, Mohali 140306, Punjab, India.
Department of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdulziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia.
Int J Pharm. 2023 Jan 25;631:122407. doi: 10.1016/j.ijpharm.2022.122407. Epub 2022 Nov 17.
Nanotechnology has received increasing attention in the past decade and it's being used as a model for developing better treatments for a variety of diseases. Despite the fact that nanotechnology-based therapy has greatly improved treatment regimens, it still faces challenges such as inadequate circulation, insufficient accumulation at the target region, and undesired toxicity. In this regard, scientists are working on producing cell-membrane camouflaged nanoparticles as a biomimetic technique for modifying the surface of existing nanoparticles to produce significant therapeutic benefits following imparting myriad of desired functionalities. Membranes originating from erythrocytes, white blood cells, cancer cells, stem cells, platelets, or bacterial cells have been used to coat nanoparticle surfaces and create biologically inspired camouflaged nanoparticles. These biomemitic delivery systems have been proven to have potential applications in diagnosing and treating vaiorus diseases, including drug administration, immunisation, immunological regulation, and detoxification. From its inception to the present, we provide a complete description of this advanced technique for functionalizing nanoparticle surfaces. The method of making these membrane coated nanoparticles as well as their characterisation have been thoroughly discussed. Following that, we focused on the diversity of cell membranes derived from distinct cells in the evolution of nanoparticles, emphasising how these biologically inspired stealth - camouflaged techniques have led to increased therapeutic efficacy in a variety of disease states.
在过去十年中，纳米技术受到了越来越多的关注，并且正被用作开发针对多种疾病的更好治疗方法的模型。尽管基于纳米技术的疗法极大地改善了治疗方案，但它仍然面临挑战，如循环不足、在靶区域积累不足以及意外的毒性。在这方面，科学家们正在致力于生产细胞膜伪装的纳米颗粒，这是一种仿生技术，用于修饰现有纳米颗粒的表面，在赋予众多所需功能后产生显著的治疗效果。源自红细胞、白细胞、癌细胞、干细胞、血小板或细菌细胞的膜已被用于包覆纳米颗粒表面，并制造出具有生物启发性的伪装纳米颗粒。这些仿生递送系统已被证明在诊断和治疗各种疾病方面具有潜在应用，包括药物给药、免疫、免疫调节和解毒。从其诞生到现在，我们对这种使纳米颗粒表面功能化的先进技术进行了全面描述。制备这些膜包覆纳米颗粒的方法及其表征已得到充分讨论。随后，我们关注了纳米颗粒演变过程中源自不同细胞的细胞膜的多样性，强调了这些具有生物启发性的隐形伪装技术如何在多种疾病状态下提高了治疗效果。
