Luk Brian T, Zhang Liangfang
Department of NanoEngineering, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, United States.
Department of NanoEngineering, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, United States.
J Control Release. 2015 Dec 28;220(Pt B):600-7. doi: 10.1016/j.jconrel.2015.07.019. Epub 2015 Jul 23.
Nanoparticles can preferentially accumulate at sites of action and hold great promise to improve the therapeutic index of many drugs. While conventional methods of nanocarrier-mediated drug delivery have focused on primarily synthetic approaches, engineering strategies that combine synthetic nanoparticles with natural biomaterials have recently gained much attention. In particular, cell membrane-camouflaged nanoparticles are a new class of biomimetic nanoparticles that combine the unique functionalities of cellular membranes and engineering versatility of synthetic nanomaterials for effective delivery of therapeutic agents. Herein, we report on the recent progress on cell membrane-coated nanoparticles for drug delivery. In particular, we highlight three areas: (i) prolonging systemic circulation via cell membrane coating, (ii) cell-specific targeting via cell membrane coating, and (iii) applications of cell membrane coating for drug delivery. The cell membrane-camouflaged nanoparticle platform has emerged as a novel delivery strategy with the potential to improve the therapeutic efficacy for the treatment of a variety of diseases.
纳米颗粒能够优先在作用部位蓄积，在提高多种药物的治疗指数方面具有巨大潜力。虽然传统的纳米载体介导的药物递送方法主要集中在合成方法上，但将合成纳米颗粒与天然生物材料相结合的工程策略最近备受关注。特别是，细胞膜伪装的纳米颗粒是一类新型的仿生纳米颗粒，它结合了细胞膜的独特功能和合成纳米材料的工程多功能性，用于有效递送治疗剂。在此，我们报道了细胞膜包覆纳米颗粒用于药物递送的最新进展。特别地，我们强调三个方面：（i）通过细胞膜包覆延长全身循环时间，（ii）通过细胞膜包覆实现细胞特异性靶向，以及（iii）细胞膜包覆在药物递送中的应用。细胞膜伪装的纳米颗粒平台已成为一种新型递送策略，具有提高多种疾病治疗疗效的潜力。
