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CERAD单词列表记忆测试:基于挪威70岁及以上健康老年人的人群样本的规范数据。HUNT研究。

The CERAD Word List Memory Test: Normative Data Based on a Norwegian Population-Based Sample of Healthy Older Adults 70 Years and Above. The HUNT Study.

作者信息

Wagle Jørgen, Selbæk Geir, Benth Jūratė Šaltytė, Gjøra Linda, Rønqvist Thale Kinne, Bekkhus-Wetterberg Peter, Persson Karin, Engedal Knut

机构信息

The Norwegian National Centre for Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.

Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.

出版信息

J Alzheimers Dis. 2023;91(1):321-343. doi: 10.3233/JAD-220672.

Abstract

BACKGROUND

The CERAD Word List Memory Test (WLMT) is widely used in the assessment of older adults with suspected dementia. Although normative data of the WLMT exist in many different regions of the world, normative data based on large population-based cohorts from the Scandinavian countries are lacking.

OBJECTIVE

To develop normative data for the WLMT based on a large population-based Norwegian sample of healthy older adults aged 70 years and above, stratified by age, gender, and education.

METHODS

A total of 6,356 older adults from two population-based studies in Norway, HUNT4 70 + and HUNT4 Trondheim 70+, were administered the WLMT. Only persons with normal cognitive function were included. We excluded persons with a diagnosis of mild cognitive impairment (MCI) and dementia, and persons with a history of stroke and/or depression. This resulted in 3,951 persons aged between 70 and 90 years, of whom 56.2% were females. Regression-based normative data were developed for this sample.

RESULTS

Age, gender, and education were significant predictors of performance on the WLMT list-learning subtests and the delayed recall subtest, i.e., participants of younger age, female sex, and higher education level attained higher scores compared to participants of older age, male sex, and lower level of education.

CONCLUSION

Regression-based normative data from the WMLT, stratified by age, gender, and education from a large population-based Norwegian sample of cognitively healthy older adults aged 70 to 90 years are presented. An online norm calculator is available to facilitate scoring of the subtests (in percentiles and z-scores).

摘要

背景

CERAD词汇表记忆测试(WLMT)广泛用于评估疑似痴呆的老年人。尽管世界许多不同地区都有WLMT的常模数据,但缺乏基于斯堪的纳维亚国家大规模人群队列的常模数据。

目的

基于挪威一个以70岁及以上健康老年人为样本的大规模人群队列,按年龄、性别和教育程度分层,制定WLMT的常模数据。

方法

对挪威两项基于人群的研究HUNT4 70+和HUNT4特隆赫姆70+中的6356名老年人进行了WLMT测试。仅纳入认知功能正常的人。我们排除了诊断为轻度认知障碍(MCI)和痴呆的人,以及有中风和/或抑郁症病史的人。这产生了3951名年龄在70至90岁之间的人,其中56.2%为女性。为该样本制定了基于回归的常模数据。

结果

年龄、性别和教育程度是WLMT列表学习子测试和延迟回忆子测试表现的显著预测因素,即与年龄较大、男性和教育程度较低的参与者相比,年龄较小、女性和教育程度较高的参与者得分更高。

结论

呈现了来自WMLT的基于回归的常模数据,该数据按年龄、性别和教育程度分层,来自挪威一个以70至90岁认知健康老年人为样本的大规模人群队列。可使用在线常模计算器来方便子测试的评分(以百分位数和z分数表示)。

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