Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Clinical Pharmacy and Translational Science, University of Tennessee Health Science Center, Memphis, TN, USA.
Trends Microbiol. 2023 Dec;31(12):1287-1299. doi: 10.1016/j.tim.2023.08.003. Epub 2023 Aug 26.
While the fungus Candida albicans is a common colonizer of healthy humans, it is also responsible for mucosal infections and severe invasive disease. Understanding the mechanisms that allow C. albicans to exist as both a benign commensal and as an invasive pathogen have been the focus of numerous studies, and recent findings indicate an important role for cross-kingdom interactions on C. albicans biology. This review highlights how C. albicans-bacteria interactions influence healthy polymicrobial community structure, host immune responses, microbial pathogenesis, and how dysbiosis may lead to C. albicans infection. Finally, we discuss how cross-kingdom interactions represent an opportunity to identify new antivirulence compounds that target fungal infections.
虽然白色念珠菌是健康人体常见的定植菌，但它也是黏膜感染和严重侵袭性疾病的罪魁祸首。了解使白色念珠菌既能作为良性共生菌又能作为侵袭性病原体存在的机制一直是众多研究的重点，最近的研究结果表明，种间相互作用对白色念珠菌生物学具有重要作用。本文综述了白色念珠菌与细菌相互作用如何影响健康的多微生物群落结构、宿主免疫反应、微生物发病机制，以及菌群失调如何导致白色念珠菌感染。最后，我们讨论了种间相互作用如何为鉴定靶向真菌感染的新型抗毒力化合物提供机会。
