Mears Jason A, Ramachandran Rajesh
Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Center for Mitochondrial Diseases, Case Western Reserve University School of Medicine, Cleveland, OH 44106.
Curr Opin Physiol. 2022 Oct;29. doi: 10.1016/j.cophys.2022.100574. Epub 2022 Jul 15.
Dynamin-related protein 1 (Drp1), the master regulator of mitochondrial division (MD), interacts with the cytoskeletal elements, namely filamentous actin (F-actin), microtubules (MT), and septins that coincidentally converge at MD sites. However, the mechanistic contributions of these critical elements to, and their cooperativity in, MD remain poorly characterized. Emergent data indicate that the cytoskeleton plays combinatorial modulator, mediator, and effector roles in MD by 'priming' and 'channeling' Drp1 for mechanoenzymatic membrane remodeling. In this brief review, we will outline our current understanding of Drp1-cytoskeleton interactions, focusing on recent progress in the field and a plausible 'diffusion barrier' role for the cytoskeleton in MD.
动力相关蛋白1（Drp1）是线粒体分裂（MD）的主要调节因子，它与细胞骨架成分相互作用，即丝状肌动蛋白（F-肌动蛋白）、微管（MT）和隔膜蛋白，这些成分恰好汇聚于MD位点。然而，这些关键成分对MD的机制贡献及其在MD中的协同作用仍未得到充分表征。新出现的数据表明，细胞骨架通过“启动”和“引导”Drp1进行机械酶促膜重塑，在MD中发挥组合调节、介导和效应作用。在这篇简短的综述中，我们将概述我们目前对Drp1-细胞骨架相互作用的理解，重点关注该领域的最新进展以及细胞骨架在MD中可能的“扩散屏障”作用。
