Collins O C, Duffy K J
Institute of Systems Science, Durban University of Technology, Durban, 4000, South Africa.
Infect Dis Model. 2022 Nov 5;7(4):728-741. doi: 10.1016/j.idm.2022.10.005. eCollection 2022 Dec.
Malaria is a life-threatening disease endemic in many African countries especially Nigeria. A mathematical model is used to study the dynamics of malaria in Nigeria. The model incorporates drug resistance, treatment, and the use of mosquito nets as preventive strategies. By fitting the model to data on the incidence of malaria in Nigeria, important parameters associated with the disease dynamics are estimated. Using these estimated parameters, the basic reproduction number is calculated, future dynamics simulated, and those parameters with a large impact on Nigerian malaria determined. Overall, the results indicate that the disease is likely to remain endemic in Nigeria unless better control measures are focused on the dominant resistant strain, treatment is improved and the use of mosquito nets become widespread.
疟疾是一种危及生命的疾病,在许多非洲国家尤其是尼日利亚流行。使用数学模型来研究尼日利亚疟疾的动态变化。该模型纳入了耐药性、治疗以及使用蚊帐作为预防策略。通过将模型与尼日利亚疟疾发病率数据拟合,估计了与疾病动态相关的重要参数。利用这些估计参数,计算基本再生数,模拟未来动态,并确定对尼日利亚疟疾有重大影响的那些参数。总体而言,结果表明,除非针对主要耐药菌株采取更好的控制措施、改善治疗并广泛使用蚊帐,否则该疾病很可能在尼日利亚继续流行。