Department of Surgery, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Centre for Clinical Trial, Institute for Clinical Research, Hospital Ampang, Ampang, Selangor, Malaysia.
PLoS One. 2022 Nov 21;17(11):e0277982. doi: 10.1371/journal.pone.0277982. eCollection 2022.
Regular physical activity (PA) after a breast cancer diagnosis is associated with reduced mortality and better quality of life. In this prospective cohort study, we aimed to explore the trends of PA among breast cancer survivors over three years and identify factors associated with low PA. Interviews on 133 breast cancer patients were conducted at baseline, one and three years after the diagnosis of breast cancer at University Malaya Medical Centre in Kuala Lumpur. Physical activity was measured by using the Global Physical Activity Questionnaire. PA was categorised as active (≥ 600 MET-min/week) and inactive (<600 MET-min/week). We used the generalised estimating equation method to examine PA levels and factors affecting PA longitudinally. The survivors' mean age was 56.89 (±10.56) years; half were Chinese (50.4%), and 70.7% were married. At baseline, 48.1% of the patients were active, but the proportion of active patients declined to 39.8% at one year and 35.3% in the third year. The mean total PA decreased significantly from 3503±6838.3 MET-min/week to 1494.0±2679.8 MET-min/week (one year) and 792.5±1364 MET-min/week (three years) (p<0.001). Three years after diagnosis (adjusted odds ratio [AOR]: 1.74, p = 0.021); Malay ethnicity (AOR: 1.86, p = 0.042) and being underweight (AOR: 3.43, p = 0.004) were significantly associated with inactivity. We demonstrated that breast cancer survivors in Malaysia had inadequate PA levels at diagnosis, which decreased over time. Thus, it is vital to communicate about the benefits of PA on cancer outcomes and continue to encourage breast cancer survivors to be physically active throughout the extended survivorship period, especially in the Malay ethnic group and underweight patients.
定期进行身体活动（PA）对乳腺癌患者有益，可降低死亡率和提高生活质量。在这项前瞻性队列研究中，我们旨在探索马来西亚大学医学中心的乳腺癌幸存者三年内 PA 变化趋势，并确定与低 PA 相关的因素。在诊断出乳腺癌后 1 年和 3 年，对 133 名乳腺癌患者在吉隆坡的马来西亚大学医学中心进行了采访。使用全球体力活动问卷（Global Physical Activity Questionnaire）来测量身体活动。将身体活动分为活跃（≥600 代谢当量-分钟/周）和不活跃（＜600 代谢当量-分钟/周）。我们使用广义估计方程方法来检查 PA 水平和随时间变化影响 PA 的因素。幸存者的平均年龄为 56.89（±10.56）岁；一半是中国人（50.4%），70.7%已婚。基线时，48.1%的患者是活跃的，但活跃患者的比例在 1 年时下降到 39.8%，在第 3 年时下降到 35.3%。总的 PA 平均值从 3503±6838.3MET-min/周显著下降到 1494.0±2679.8MET-min/周（1 年）和 792.5±1364MET-min/周（3 年）（p＜0.001）。诊断 3 年后（调整后的优势比 [AOR]：1.74，p = 0.021）；马来族裔（AOR：1.86，p = 0.042）和体重不足（AOR：3.43，p = 0.004）与不活跃显著相关。我们表明，马来西亚的乳腺癌幸存者在诊断时的 PA 水平不足，且随时间推移而下降。因此，重要的是要传达 PA 对癌症结果的益处，并继续鼓励乳腺癌幸存者在整个延长的生存期间保持身体活跃，尤其是在马来族裔和体重不足的患者中。
