Microbiota I-Center, Hong Kong SAR, China; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China; Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Microbiota I-Center, Hong Kong SAR, China; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; Li Ka Shing Institute of Health Sciences, State Key Laboratory of Digestive Disease, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong SAR, China; Center for Gut Microbiota Research, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Clin Microbiol Infect. 2023 Jun;29(6):689-694. doi: 10.1016/j.cmi.2022.11.012. Epub 2022 Nov 19.
Bacteriophages are a major component of the human gut microbiota. Emerging evidence suggests that gut bacteriophages play an important role in the intricate dynamics with bacteria, and their transfer may be associated with the efficacy of faecal microbiota transplantation (FMT).
To summarize our current knowledge of the changes in gut bacteriophage communities during FMT and their association with FMT outcome.
PubMed, Web of Science, and Google Scholar were searched for articles on FMT and bacteriophages published between May 2013 and January 2022.
Preclinical and clinical studies have reported associations between gut bacteriophage profiles and FMT. FMT was associated with donor-specific engraftment of bacteriophages, characterized by increased viral diversity and richness, and the bacteriophage composition resembled the donor's profile after FMT. Limited studies showed that cure after FMT was more likely when an increased fraction of the recipient enteric virome was occupied by donor-derived taxa, including Caudovirales in Clostridioides difficile infection. Faecal virome transplant involving the transfer of the gut virome communities alone may also induce phenotypical and microbiome improvement in various diseases.
The accumulating evidence that bacteriophages play roles in FMT efficacy has attracted considerable interest. Better characterization of bacteriophages and an understanding of their underlying mechanisms in FMT are warranted.
噬菌体是人类肠道微生物群的主要组成部分。新出现的证据表明，肠道噬菌体在与细菌的复杂动态关系中发挥着重要作用，它们的转移可能与粪便微生物群移植（FMT）的疗效有关。
总结我们目前对 FMT 过程中肠道噬菌体群落变化及其与 FMT 结果的关联的认识。
检索了 2013 年 5 月至 2022 年 1 月期间发表的关于 FMT 和噬菌体的 PubMed、Web of Science 和 Google Scholar 文章。
临床前和临床研究报告了肠道噬菌体谱与 FMT 之间的关联。FMT 与噬菌体的供体特异性定植有关，表现为病毒多样性和丰富度增加，且 FMT 后噬菌体组成类似于供体的特征。有限的研究表明，当受体内肠病毒组的更大比例被供体来源的分类群占据时，包括艰难梭菌感染中的长尾病毒目，FMT 后的治愈率更高。单独涉及肠道病毒群转移的粪便病毒组移植也可能在各种疾病中诱导表型和微生物组的改善。
越来越多的证据表明噬菌体在 FMT 疗效中发挥作用，这引起了相当大的兴趣。有必要更好地描述噬菌体及其在 FMT 中的潜在机制。
