Aldabaldetrecu Maialen, Parra Mick, Soto-Aguilera Sarita, Arce Pablo, Quiroz Amaya Paz de la Vega, Segura Rodrigo, Tello Mario, Guerrero Juan, Modak Brenda
Laboratory of Coordination Compounds and Supramolecularity, Faculty of Chemistry and Biology, University of Santiago of Chile, Av. Bernardo O'Higgins 3363, Santiago 9170022, Chile.
Laboratory of Natural Products Chemistry, Centre of Aquatic Biotechnology, Faculty of Chemistry and Biology, University of Santiago of Chile, Av. Bernardo O'Higgins 3363, Santiago 9170022, Chile.
Microorganisms. 2022 Nov 19;10(11):2296. doi: 10.3390/microorganisms10112296.
Previously, we reported an in vitro evaluation regarding antibacterial effects against by a new Cu (I) complex, Cu(NN). This study presents the results of an in vivo evaluation of Cu(NN) added as a dietary supplement against in rainbow trout. The results showed that the administration of Cu(NN) at 29 and 58 µg/g of fish for 15 days does not affect the growth of rainbow trout. On the other hand, the amount of copper present in the liver, intestine, and muscle of rainbow trout was determined. The results showed that the amount of copper in the liver, when compared between treated fish and control fish, does not change. While, in the intestine, an increase in the fish fed at 58 µg/g of fish was observed. In muscle, a slight decrease at 29 µg/g was obtained. Additionally, copper concentrations in the pond water after 15 days of feeding with the Cu(NN) complex showed the highest levels of copper. Finally, the effect of the administration of Cu(NN) for 15 days at 58 µg/g of fish was evaluated against , where a 75% survival was obtained during 20 days of challenge.
此前，我们报道了一种新型铜（I）配合物Cu(NN)对[具体细菌名称未给出]的体外抗菌效果评估。本研究展示了将Cu(NN)作为膳食补充剂添加到虹鳟鱼饲料中进行体内评估的结果。结果表明，以29和58微克/克鱼的剂量投喂Cu(NN) 15天，对虹鳟鱼的生长没有影响。另一方面，测定了虹鳟鱼肝脏、肠道和肌肉中的铜含量。结果显示，与对照鱼相比，处理过的鱼肝脏中的铜含量没有变化。而在肠道中，观察到投喂58微克/克鱼的鱼体内铜含量增加。在肌肉中，29微克/克剂量时略有下降。此外，用Cu(NN)配合物投喂15天后池塘水中的铜浓度显示出最高水平的铜。最后，评估了以58微克/克鱼的剂量投喂Cu(NN) 15天对[具体细菌名称未给出]的效果，在20天的攻毒试验中获得了75%的存活率。
