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[具体物质]对上呼吸道感染病原体的抗菌及抗生物膜活性

Antimicrobial and Antibiofilm Activities of against Pathogens of Upper Respiratory Tract Infections.

作者信息

Yeu Ji-Eun, Lee Hyeon-Gyu, Park Geun-Yeong, Lee Jisun, Kang Mi-Sun

机构信息

R&D Center, OraPharm, Inc., Seoul 04782, Korea.

Department of Food and Nutrition, Hanyang University, Seoul 04763, Korea.

出版信息

Microorganisms. 2021 May 30;9(6):1181. doi: 10.3390/microorganisms9061181.

DOI:10.3390/microorganisms9061181
PMID:34070813
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8229644/
Abstract

Recently discovered preventive effects of probiotics on oral health have attracted interest to their use for the prevention and treatment of various diseases. This study aimed to evaluate the antimicrobial and antibiofilm properties of against , , . , and , the major pathogens of upper respiratory tract infections (URTIs). The antimicrobial activities of . were compared with those of other oral probiotics using a competitive inhibition assay and the determination of the minimum inhibitory concentrations (MICs). In addition, a time-kill assay, spectrophotometry, and confocal laser scanning microscopy were used to confirm the antimicrobial and antibiofilm abilities of . CMU (oraCMU) and CMS1 (oraCMS1). Both live cells and cell-free supernatants of all tested probiotics, except , showed excellent antimicrobial activities. All target pathogens were killed within 4 to 24 h at twice the MIC of oraCMU and oraCMS1, which showed the highest antimicrobial activities against . . The antimicrobial substances that affected different target pathogens were different. Both oraCMU and oraCMS1 showed excellent abilities to inhibit biofilm formation and remove preformed biofilms. Our results suggest that the . probiotics offer new possibilities for the prevention and treatment of bacterial URTIs.

摘要

最近发现益生菌对口腔健康具有预防作用，这引发了人们对其用于预防和治疗各种疾病的兴趣。本研究旨在评估[具体益生菌名称]对[具体病原体名称1]、[具体病原体名称2]、[具体病原体名称3]、[具体病原体名称4]和[具体病原体名称5]（上呼吸道感染（URTIs）的主要病原体）的抗菌和抗生物膜特性。使用竞争抑制试验和最低抑菌浓度（MICs）测定法，将[具体益生菌名称]的抗菌活性与其他口服益生菌的抗菌活性进行比较。此外，还使用了时间杀菌试验、分光光度法和共聚焦激光扫描显微镜来确认[具体益生菌名称]CMU（oraCMU）和CMS1（oraCMS1）的抗菌和抗生物膜能力。除[具体益生菌名称]外，所有测试益生菌的活细胞和无细胞上清液均表现出优异的抗菌活性。在oraCMU和oraCMS1的两倍MIC浓度下，所有目标病原体在4至24小时内被杀死，这两种益生菌对[具体病原体名称]表现出最高的抗菌活性。影响不同目标病原体的抗菌物质不同。oraCMU和oraCMS1均表现出优异的抑制生物膜形成和去除预先形成的生物膜的能力。我们的结果表明，[具体益生菌名称]益生菌为细菌性URTIs的预防和治疗提供了新的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/bcffe70fdf9d/microorganisms-09-01181-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/2ce6f388f2e2/microorganisms-09-01181-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/2a294e73b419/microorganisms-09-01181-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/ebc890053711/microorganisms-09-01181-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/4777875dacf9/microorganisms-09-01181-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/f7bfc3141d80/microorganisms-09-01181-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/158afac3df39/microorganisms-09-01181-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/bcffe70fdf9d/microorganisms-09-01181-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/2ce6f388f2e2/microorganisms-09-01181-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/2a294e73b419/microorganisms-09-01181-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/ebc890053711/microorganisms-09-01181-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/4777875dacf9/microorganisms-09-01181-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/f7bfc3141d80/microorganisms-09-01181-g005a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/158afac3df39/microorganisms-09-01181-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfc/8229644/bcffe70fdf9d/microorganisms-09-01181-g007.jpg

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