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初始手术紧迫性对体外膜肺氧合治疗的心内直视术后心源性休克患者短期预后的影响。

Impact of Initial Operative Urgency on Short-Term Outcomes in Patients Treated with ECMO Due to Postcardiotomy Cardiogenic Shock.

作者信息

Ivanov Borko, Krasivskyi Ihor, Gerfer Stephen, Sabashnikov Anton, Doss Mirko, Holzhey David, Eghbalzadeh Kaveh, Rustenbach Christian, Kuhn Elmar, Rahmanian Parwis Baradaran, Mader Navid, Djordjevic Ilija, Wahlers Thorsten

机构信息

Department of Cardiothoracic Surgery, Heart Centre, Helios Hospital Siegburg, 53721 Siegburg, Germany.

Department of Cardiothoracic Surgery, Heart Centre, University Hospital Cologne, 50937 Cologne, Germany.

出版信息

Life (Basel). 2022 Nov 13;12(11):1872. doi: 10.3390/life12111872.

Abstract

The outcomes of patients with PCS and following ECMO therapy are associated with several preoperative risk factors. Our aim was to compare clinical presentation, ECMO-related data and in-hospital outcomes of patients treated with ECMO due to PCS after cardiac surgery, in regard to elective or emergent cardiac surgery procedures. Between April 2006 and October 2016, 164 consecutive patients that received VA-ECMO therapy due to PCS were identified and included in this retrospective cohort study. The patients were divided into groups based on the urgency of the initial procedures performed: elective group (ELG; n = 95) and an emergency group (EMG; n = 69). To compare the unequal patient groups, a propensity score-based matching (PSM) was applied (ELG, n = 56 vs. EMG, n = 56). The EMG primarily received ECMO intraoperatively (p ≤ 0.001). In contrast, the ELG were needed ECMO support more frequently postoperatively (p < 0.001). In-hospital mortality accounted for 71% (n = 40) in the ELG and 76% (n = 43) in the EMG (p = 0.518). Outcome data showed no major differences in the (abdominal ischemia (p = 0.371); septic shock (p = 0.393): rhythm disturbances (p = 0.575); emergency re-thoracotomy (p = 0.418)) between the groups. The urgency of the initial procedures performed is secondary in patients suffering PCS and following ECMO. In this regard, PCS itself seems to trigger outcomes in cardiac surgery ECMO patients substantially.

摘要

心脏术后心源性休克(PCS)患者接受体外膜肺氧合(ECMO)治疗的结果与多种术前危险因素相关。我们的目的是比较因心脏术后PCS接受ECMO治疗的患者在择期或急诊心脏手术中的临床表现、ECMO相关数据及院内结局。2006年4月至2016年10月,164例因PCS接受VA-ECMO治疗的连续患者被纳入本回顾性队列研究。根据首次手术的紧急程度将患者分为两组:择期组(ELG;n = 95)和急诊组(EMG;n = 69)。为比较不均衡的患者组,应用基于倾向评分的匹配(PSM)(ELG,n = 56 vs. EMG,n = 56)。急诊组主要在术中接受ECMO治疗(p≤0.001)。相比之下,择期组术后更频繁需要ECMO支持(p < 0.001)。院内死亡率在择期组为71%(n = 40),急诊组为76%(n = 43)(p = 0.518)。结局数据显示两组间在腹部缺血(p = 0.371)、感染性休克(p = 0.393)、心律失常(p = 0.575)、急诊再次开胸手术(p = 0.418)方面无显著差异。对于PCS及接受ECMO治疗的患者,首次手术的紧急程度是次要的。在这方面,PCS本身似乎在很大程度上引发了心脏手术ECMO患者的结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d18/9696618/5bde393a70e4/life-12-01872-g001.jpg

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