Balogh László, Szabó Krisztina, Pucsok József Márton, Jámbor Ilona, Gyetvai Ágnes, Mile Marianna, Barna Lilla, Szodoray Peter, Tarr Tünde, Csiki Zoltán, Papp Gábor
Institute of Sport Sciences, University of Debrecen, H-4032 Debrecen, Hungary.
Division of Clinical Immunology, Institute of Internal Medicine, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.
J Clin Med. 2022 Nov 17;11(22):6814. doi: 10.3390/jcm11226814.
Growing evidence indicates the pronounced effects of physical activity on immune functions, which may largely depend on the type of exercise, intensity, and duration. However, limited information is available regarding the effects of low-impact exercises, especially on the level of adaptive immune system. Our study aimed to investigate and compare the changes in a broad spectrum of lymphocyte subtypes after 14 weeks of aerobic-type total-body-shaping workouts (TBSW) and Pilates workouts (PW) among healthy individuals. We determined the percentages of peripheral natural killer cells and different T and B lymphocyte subtypes with flow cytometry. At the end of the exercise program, significant changes in naïve and memory lymphocyte ratios were observed in TBSW group. Percentages of naïve cytotoxic T (Tc) cells elevated, frequencies of memory Tc and T-helper cell subsets decreased, and distribution of naïve and memory B cells rearranged. Proportions of activated T cells also showed significant changes. Nonetheless, percentages of anti-inflammatory interleukin (IL)-10-producing regulatory type 1 cells and immunosuppressive CD4CD127CD25 T regulative cells decreased not only after TBSW but also after PW. Although weekly performed aerobic workouts may have a more pronounced impact on the adaptive immune system than low-impact exercises, both still affect immune regulation in healthy individuals.
越来越多的证据表明体育活动对免疫功能有显著影响，这在很大程度上可能取决于运动类型、强度和持续时间。然而，关于低强度运动的影响，尤其是对适应性免疫系统水平的影响，目前可用信息有限。我们的研究旨在调查和比较健康个体在进行14周有氧型全身塑形锻炼（TBSW）和普拉提锻炼（PW）后多种淋巴细胞亚群的变化。我们用流式细胞术测定外周自然杀伤细胞以及不同T和B淋巴细胞亚群的百分比。在锻炼计划结束时，TBSW组的初始和记忆淋巴细胞比例出现了显著变化。初始细胞毒性T（Tc）细胞百分比升高，记忆Tc细胞和辅助性T细胞亚群频率降低，初始和记忆B细胞分布重新排列。活化T细胞比例也有显著变化。尽管如此，不仅在TBSW后，而且在PW后，产生抗炎性白细胞介素（IL）-10的1型调节细胞和免疫抑制性CD4CD127CD25 T调节细胞的百分比均下降。虽然每周进行的有氧锻炼可能比低强度运动对适应性免疫系统有更显著的影响，但两者仍会影响健康个体的免疫调节。
