Xu Bai, Yin Man, Yang Yaming, Zou Yunlong, Liu Wenbin, Qiao Lianyong, Zhang Jixiang, Wang Zhan, Wu Yayu, Shen He, Sun Minghan, Liu Weiyuan, Xue Weiwei, Fan Yongheng, Zhang Qi, Chen Bing, Wu Xianming, Shi Ya, Lu Falong, Zhao Yannan, Xiao Zhifeng, Dai Jianwu
State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China.
Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, China.
Bioact Mater. 2022 Nov 23;23:300-313. doi: 10.1016/j.bioactmat.2022.11.008. eCollection 2023 May.
Neural stem progenitor cell (NSPC) transplantation has been regarded as a promising therapeutic method for spinal cord injury (SCI) repair. However, different NSPCs may have different therapeutic effects, and it is therefore important to identify the optimal NSPC type. In our study, we compared the transcriptomes of human fetal brain-derived NSPCs (BNSPCs), spinal cord-derived NSPCs (SCNSPCs) and H9 embryonic stem-cell derived NSPCs (H9-NSPCs) and subsequently we transplanted each NSPC type on a collagen scaffold into a T8-9 complete SCI rat model . data showed that SCNSPCs had more highly expressed genes involved in nerve-related functions than the other two cell types. , compared with BNSPCs and H9-NSPCs, SCNSPCs exhibited the best therapeutic effects; in fact, SCNSPCs facilitated electrophysiological and hindlimb functional recovery. This study demonstrates that SCNSPCs may be an appropriate candidate cell type for SCI repair, which is of great clinical significance.
神经干祖细胞（NSPC）移植被认为是一种有前景的脊髓损伤（SCI）修复治疗方法。然而，不同的NSPC可能具有不同的治疗效果，因此确定最佳的NSPC类型很重要。在我们的研究中，我们比较了人胎脑来源的NSPC（BNSPC）、脊髓来源的NSPC（SCNSPC）和H9胚胎干细胞来源的NSPC（H9-NSPC）的转录组，随后我们将每种NSPC类型接种在胶原支架上移植到T8-9完全性SCI大鼠模型中。数据显示，与其他两种细胞类型相比，SCNSPC中参与神经相关功能的基因表达更高。与BNSPC和H9-NSPC相比，SCNSPC表现出最佳的治疗效果；事实上，SCNSPC促进了电生理和后肢功能恢复。这项研究表明，SCNSPC可能是SCI修复的合适候选细胞类型，具有重要的临床意义。
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