Comprehensive analysis of the expression profile and clinical implications of regulator of chromosome condensation 2 in pan-cancers.

The Regulator of Chromosome Condensation 2 (RCC2) is an important gene that regulates mitosis and cytoplasmic division in the cell cycle. Although there have been reported in several individual tumors, an integrative analysis of and its clinical significance across diverse cancer types is poorly elucidated. In this study, we performed integrative bioinformatics analyses to profile the expression landscape and assess the prognostic value of in pan-cancers. Correlations between expression and tumor-infiltrating immune cells, tumor mutation burden (TMB), microsatellite instability (MSI), chemokine and their receptors were analyzed using TCGA, ESTIMATE algorithm, and TISIDB database. We also explored the potential molecular functions of through functional enrichment analysis and protein interaction networks. We discovered that was highly expressed in various tumor tissues and was closely associated with cancer prognosis. Different -associated immune infiltration patterns were exhibited in different tumor-infiltrating immune cells. In addition, the had a potential role in regulating the tumor immune microenvironment and the formation of cancer-associated fibroblasts (CAFs). Meanwhile, showed a significant correlation with TMB, MSI, chemokines and their receptors in different tumor types. The role of as a clinical therapeutic target was further revealed from the perspective of the immune microenvironment. In conclusion, is closely associated with tumorigenesis and cancer-immune infiltration, and could be a promising prognostic and therapeutic biomarker in diverse cancers.