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1
A computer aided oligonucleotide analysis provides a model sequence for RNA polymerase-promoter recognition in E.coli.计算机辅助的寡核苷酸分析为大肠杆菌中RNA聚合酶-启动子识别提供了一个模型序列。
Nucleic Acids Res. 1978 Oct;5(10):3759-73. doi: 10.1093/nar/5.10.3759.
2
Unusual location and function of the operator in the Escherichia coli galactose operon.大肠杆菌半乳糖操纵子中操纵基因的异常定位与功能
Nature. 1979 Jun 7;279(5713):494-500. doi: 10.1038/279494a0.
3
Spacing requirements for interactions between the C-terminal domain of the alpha subunit of Escherichia coli RNA polymerase and the cAMP receptor protein.大肠杆菌RNA聚合酶α亚基C末端结构域与cAMP受体蛋白之间相互作用的间距要求。
Biochem J. 1998 Feb 15;330 ( Pt 1)(Pt 1):413-20. doi: 10.1042/bj3300413.
4
Genetic regulation: the Lac control region.基因调控：乳糖操纵子控制区
Science. 1975 Jan 10;187(4171):27-35. doi: 10.1126/science.1088926.
5
Investigations of Escherichia coli promoter sequences with artificial neural networks: new signals discovered upstream of the transcriptional startpoint.利用人工神经网络对大肠杆菌启动子序列进行的研究：在转录起始点上游发现新信号。
Proc Int Conf Intell Syst Mol Biol. 1995;3:292-9.
6
Selection of DNA binding sites by regulatory proteins. II. The binding specificity of cyclic AMP receptor protein to recognition sites.调节蛋白对DNA结合位点的选择。II. 环磷酸腺苷受体蛋白对识别位点的结合特异性。
J Mol Biol. 1988 Apr 20;200(4):709-23. doi: 10.1016/0022-2836(88)90482-2.
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Action of CAP on the malT promoter in vitro.CAP对malT启动子的体外作用。
J Bacteriol. 1983 Dec;156(3):1135-43. doi: 10.1128/jb.156.3.1135-1143.1983.
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Structure and function of E. coli promoter DNA.
CRC Crit Rev Biochem. 1987;22(3):181-219. doi: 10.3109/10409238709101483.
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Binding of RNA polymerase and the catabolite gene activator protein within the cat promoter in Escherichia coli.RNA聚合酶与分解代谢基因激活蛋白在大肠杆菌中cat启动子内的结合。
J Mol Biol. 1981 Aug 5;150(2):185-96. doi: 10.1016/0022-2836(81)90448-4.
10
Cyclic AMP receptor protein and RhaR synergistically activate transcription from the L-rhamnose-responsive rhaSR promoter in Escherichia coli.环腺苷酸受体蛋白与RhaR协同激活大肠杆菌中L-鼠李糖反应性rhaSR启动子的转录。
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Isolation and Mapping of Small Cauliflower Mosaic Virus DNA Fragments Active as Promoters in Escherichia coli.在大肠杆菌中作为启动子具有活性的小花椰菜花叶病毒DNA小片段的分离与定位
J Virol. 1981 Feb;37(2):673-82. doi: 10.1128/JVI.37.2.673-682.1981.
2
The ribosome binding sites recognized by E. coli ribosomes have regions with signal character in both the leader and protein coding segments.大肠杆菌核糖体识别的核糖体结合位点在前导序列和蛋白质编码序列中都有具有信号特征的区域。
Nucleic Acids Res. 1980 Sep 11;8(17):3895-907. doi: 10.1093/nar/8.17.3895.
3
Antibodies against the subunits of E. coli RNA polymerase as probes for subunit-specific binding of DNA and other ligands.针对大肠杆菌RNA聚合酶亚基的抗体，作为DNA和其他配体亚基特异性结合的探针。
Nucleic Acids Res. 1980 Mar 25;8(6):1405-20. doi: 10.1093/nar/8.6.1405.
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Spacer DNA sequences upstream of the T-A-T-A-A-A-T-A sequence are essential for promotion of H2A histone gene transcription in vivo.T-A-T-A-A-A-T-A序列上游的间隔DNA序列对于体内H2A组蛋白基因转录的促进至关重要。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7102-6. doi: 10.1073/pnas.77.12.7102.
5
DNA sequence of regulatory region for integration gene of bacteriophage lambda.噬菌体λ整合基因调控区的DNA序列
Proc Natl Acad Sci U S A. 1980 May;77(5):2477-81. doi: 10.1073/pnas.77.5.2477.
6
A computer algorithm for testing potential prokaryotic terminators.一种用于测试潜在原核生物终止子的计算机算法。
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7
Nucleotide sequence of the ilvB multivalent attenuator region of Escherichia coli K12.大肠杆菌K12 ilvB多价弱化子区域的核苷酸序列。
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8
Nucleotide sequence of Escherichia coli pabB indicates a common evolutionary origin of p-aminobenzoate synthetase and anthranilate synthetase.大肠杆菌pabB的核苷酸序列表明对氨基苯甲酸合成酶和邻氨基苯甲酸合成酶有共同的进化起源。
J Bacteriol. 1984 Jul;159(1):57-62. doi: 10.1128/jb.159.1.57-62.1984.
9
Initiation and termination signals for transcription in bacteriophage M13.噬菌体M13转录的起始和终止信号
Nucleic Acids Res. 1984 May 25;12(10):4071-81. doi: 10.1093/nar/12.10.4071.
10
Biological expression of an Escherichia coli consensus sequence promoter and some mutant derivatives.大肠杆菌共有序列启动子及其一些突变衍生物的生物学表达。
Proc Natl Acad Sci U S A. 1983 Jun;80(11):3203-7. doi: 10.1073/pnas.80.11.3203.

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The nucleotide sequence preceding an RNA polymerase initiation site on SV40 DNA. Part 2. The sequence of the early strand transcript.猴病毒40（SV40）DNA上RNA聚合酶起始位点之前的核苷酸序列。第2部分。早期链转录本的序列。
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The nucleotide sequence preceding an RNA polymerase initiation site on SV40 DNA. Part 1. The sequence of the late strand transcript.猴病毒40（SV40）DNA上RNA聚合酶起始位点之前的核苷酸序列。第1部分。晚期链转录本的序列。
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Molecular conformations and structure transitions of RNA complementary helices and their possible biological significance.RNA互补螺旋的分子构象与结构转变及其可能的生物学意义。
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Repression by the cI protein of phage lambda: in vitro inhibition of RNA synthesis.噬菌体λ的cI蛋白介导的阻遏作用：体外对RNA合成的抑制
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The 5'-terminal nucleotide sequence of galactose messenger ribonucleic acid of Escherichia coli.大肠杆菌半乳糖信使核糖核酸的5'-末端核苷酸序列。
Proc Natl Acad Sci U S A. 1974 Dec;71(12):4940-4. doi: 10.1073/pnas.71.12.4940.
8
Promoters are in the operators in phage lambda.启动子存在于λ噬菌体的操纵基因中。
Nature. 1974 May 17;249(454):221-3. doi: 10.1038/249221a0.
9
The nucleotide sequence of the lactose messenger ribonucleic acid transcribed from the UV5 promoter mutant of Escherichia coli.从大肠杆菌UV5启动子突变体转录而来的乳糖信使核糖核酸的核苷酸序列。
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3585-9. doi: 10.1073/pnas.70.12.3585.
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The nucleotide sequence of the lac operator.乳糖操纵基因的核苷酸序列。
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计算机辅助的寡核苷酸分析为大肠杆菌中RNA聚合酶-启动子识别提供了一个模型序列。

A computer aided oligonucleotide analysis provides a model sequence for RNA polymerase-promoter recognition in E.coli.

作者信息

Scherer G E, Walkinshaw M D, Arnott S

出版信息

Nucleic Acids Res. 1978 Oct;5(10):3759-73. doi: 10.1093/nar/5.10.3759.

DOI:10.1093/nar/5.10.3759
PMID:364417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC342708/
Abstract

A novel computer procedure has been used to search for homology among 17 known procaryotic promoter sequences. A model sequence, :formula: (see text), is compatible with the properties of all known promoter and operator mutations, predicts base positions for the initiation of RNA synthesis coinciding with those determined experimentally, is compatible with current models for the regulation of transcription, suggests that RNA polymerase could recognize the DNA double helix firstly in the B conformation then in the A.

摘要

一种新颖的计算机程序已被用于搜索17个已知原核生物启动子序列之间的同源性。一个模型序列（见正文）与所有已知启动子和操纵基因突变的特性相符，预测RNA合成起始的碱基位置与实验确定的位置一致，与当前转录调控模型相符，表明RNA聚合酶首先可以识别B构象的DNA双螺旋，然后识别A构象的DNA双螺旋。