在 COVID-19 大流行期间，心脏移植受者对 COVID-19 疫苗的接受率较低，生活质量下降。
Low acceptance rate of COVID-19 vaccination and reduced quality of life among heart transplant recipients during the COVID-19 pandemic.
机构信息
Department of Cardiovascular Surgery, Union Hospital, Fujian Medical University, Fujian, Fuzhou, P. R. China.
Key Laboratory of Cardio-Thoracic Surgery (Fujian Medical University), Fujian Province University, Fuzhou, Fujian, P. R. China.
出版信息
J Card Surg. 2022 Dec;37(12):4975-4981. doi: 10.1111/jocs.17205. Epub 2022 Nov 29.
OBJECTIVES
To investigate the impact of the current coronavirus disease 2019 (COVID-19) pandemic on the quality of life (QoL) and status of COVID-19 vaccination in heart transplant recipients (HTRs).
METHODS
Patients who underwent allogeneic heart transplants between June 2006 and December 2019, who survived were selected from a follow-up registration form at our center. Data were collected using questionnaires in 2021, the QoL survey was conducted using the MOS 36-item Short-Form Health Survey (SF-36) and compared to the same time frame in 2019. The patients were divided into two groups: post-epidemic (A) and pre-epidemic (B) groups. We also recorded whether the participants had been vaccinated against COVID-19 (Beijing Sinovac COVID-19 vaccine). All the data obtained were analyzed.
RESULTS
There were 88 patients who participated in the study. Only 12 (13.6%) were vaccinated. In terms of SF-36 scale assessments, after the outbreak of the COVID-19 pandemic, Group A scored lower in vitality [52.5(49.0, 58.0) vs. 75.0(69.0, 79.0), p < .001], social functioning [54.0(50.5, 58.0) vs. 74.0(67.5, 78.0), p < .001], role emotional [58.5(55.0, 62.0) vs. 67.0(63.0, 71.0), p < .001], and mental health [58.5(55.0, 62.0) vs. 76.0(72.0, 79.0), p < .001]. In Group A the mental component summary (MCS) significantly decreased [222.0(214.5, 230.0) vs. 289.0(277.5, 299.5), p < .001]. The PCS and MCS of HTRs who had been vaccinated against COVID-19 were significantly higher than those who had not [PCS: 283.5(280.0, 287.0) vs. 276.0(271.0, 279.0), p < .001; MCS: 245.0(141.5, 254.0) vs. 220.0(213.5, 226.5), p < .001].
CONCLUSION
Low acceptance levels of COVID-19 vaccination were observed in the HTRs. The QoL of the HTRs decreased after the COVID-19 pandemic.
目的
探讨当前 2019 年冠状病毒病（COVID-19）大流行对心脏移植受者（HTR）生活质量（QoL）和 COVID-19 疫苗接种状况的影响。
方法
从我们中心的随访登记册中选择了 2006 年 6 月至 2019 年 12 月期间接受同种异体心脏移植且存活的患者。2021 年使用问卷收集数据，使用 MOS 36 项简短健康调查问卷（SF-36）进行 QoL 调查，并与 2019 年同一时期进行比较。患者分为两组：大流行后（A 组）和大流行前（B 组）。我们还记录了参与者是否接种了 COVID-19 疫苗（北京科兴 COVID-19 疫苗）。对所有获得的数据进行分析。
结果
共有 88 名患者参加了这项研究。只有 12 人（13.6%）接种了疫苗。在 SF-36 量表评估方面，COVID-19 大流行爆发后，A 组在活力[52.5（49.0，58.0）比 75.0（69.0，79.0），p<0.001]、社会功能[54.0（50.5，58.0）比 74.0（67.5，78.0），p<0.001]、情感角色[58.5（55.0，62.0）比 67.0（63.0，71.0），p<0.001]和心理健康[58.5（55.0，62.0）比 76.0（72.0，79.0），p<0.001]方面的评分较低。在 A 组中，心理成分综合评分（MCS）显著下降[222.0（214.5，230.0）比 289.0（277.5，299.5），p<0.001]。接种 COVID-19 疫苗的 HTRs 的生理机能（PCS）和心理成分（MCS）均显著高于未接种疫苗的 HTRs [PCS：283.5（280.0，287.0）比 276.0（271.0，279.0），p<0.001；MCS：245.0（141.5，254.0）比 220.0（213.5，226.5），p<0.001]。
结论
HTRs 对 COVID-19 疫苗的接种接受率较低。COVID-19 大流行后，HTRs 的生活质量下降。
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