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我们对天花病毒了解多少?一次从临床到治疗的探索之旅。

What Do We Know About the Smallpox Virus? A Journey Between Clinic and Therapy.

机构信息

Ministry of Health, Viale Giorgio Ribotta 5, 00144, Rome, Italy.

Pharmaceutical Department, Asl Napoli 3 Sud, Dell'amicizia street 22, 80035, Nola, Naples, Italy.

出版信息

Pharm Res. 2023 Feb;40(2):459-465. doi: 10.1007/s11095-022-03447-z. Epub 2022 Nov 30.

Abstract

PURPOSE

Modern research is increasingly focusing on the study of new viruses and the re-emergence of past microbes, such as Coronaviruses, particularly Sars-Cov2 that was responsible for the very recent pandemic.

METHODS AND RESULTS

This infection manifested itself and still continues to manifest as a severe respiratory syndrome. The main discriminator of whether or not one succeeds in overcoming this infection may depend on a great many factors, but the main one is definitely determined by vaccination, which has minimized hospitalizations and more severe syndromes.

CONCLUSION

Recently, a new virus, the monkeypox virus, which was previously confined to Central and West Africa but is now gradually spreading to more than 30 countries including the United States of America, where such an infection is not endemic, is coming forward again.

摘要

目的

现代研究越来越关注新病毒的研究和过去微生物的重现,如冠状病毒,特别是导致最近大流行的 SARS-CoV-2。

方法和结果

这种感染表现为严重的呼吸系统综合征,并且仍在继续。一个人是否成功克服这种感染的主要区别因素可能取决于很多因素,但主要因素肯定是由疫苗接种决定的,疫苗接种使住院和更严重的综合征的人数降到了最低。

结论

最近,一种新病毒,即猴痘病毒,再次出现。该病毒以前局限于中非和西非,但现在逐渐传播到包括美国在内的 30 多个国家,而美国并非该病毒的地方性流行区。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c27f/9713125/b36edbbf97cb/11095_2022_3447_Fig1_HTML.jpg

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