Faculty of Life science and Technology, Kunming University of Science and Technology, Kunming, China.
Medical School, Kunming University of Science and Technology, Kunming, China.
Front Endocrinol (Lausanne). 2022 Nov 14;13:1010102. doi: 10.3389/fendo.2022.1010102. eCollection 2022.
Musculoskeletal system gradually degenerates with aging, and a hypoxia environment at a high altitude may accelerate this process. However, the comprehensive effects of high-altitude environments on bones and muscles remain unclear. This study aims to compare the differences in bones and muscles at different altitudes, and to explore the mechanism and influencing factors of the high-altitude environment on the skeletal muscle system.
This is a prospective, multicenter, cohort study, which will recruit a total of 4000 participants over 50 years from 12 research centers with different altitudes (50m~3500m). The study will consist of a baseline assessment and a 5-year follow-up. Participants will undergo assessments of demographic information, anthropomorphic measures, self-reported questionnaires, handgrip muscle strength assessment (HGS), short physical performance battery (SPPB), blood sample analysis, and imaging assessments (QCT and/or DXA, US) within a time frame of 3 days after inclusion. A 5-year follow-up will be conducted to evaluate the changes in muscle size, density, and fat infiltration in different muscles; the muscle function impairment; the decrease in BMD; and the osteoporotic fracture incidence. Statistical analyses will be used to compare the research results between different altitudes. Multiple linear, logistic regression and classification tree analyses will be conducted to calculate the effects of various factors (e.g., altitude, age, and physical activity) on the skeletal muscle system in a high-altitude environment. Finally, a provisional cut-off point for the diagnosis of sarcopenia in adults at different altitudes will be calculated.
The study has been approved by the institutional research ethics committee of each study center (main center number: KHLL2021-KY056). Results will be disseminated through scientific conferences and peer-reviewed publications, as well as meetings with stakeholders.
http://www.chictr.org.cn/index.aspx, identifier ChiCTR2100052153.
随着年龄的增长，肌肉骨骼系统逐渐退化，而高海拔地区的低氧环境可能会加速这一过程。然而，高海拔环境对骨骼和肌肉的综合影响尚不清楚。本研究旨在比较不同海拔地区骨骼和肌肉的差异，并探讨高海拔环境对骨骼肌系统的作用机制和影响因素。
这是一项前瞻性、多中心、队列研究，将从 12 个海拔高度不同（50m~3500m）的研究中心共招募 4000 名 50 岁以上的参与者。该研究将包括基线评估和 5 年随访。参与者将在纳入后 3 天内接受人口统计学信息、人体测量指标、自我报告问卷、握力评估（HGS）、简易体能状况量表（SPPB）、血液样本分析和影像学评估（QCT 和/或 DXA、US）。5 年随访将评估不同肌肉的肌肉大小、密度和脂肪浸润变化；肌肉功能障碍；BMD 下降；以及骨质疏松性骨折的发生率。统计分析将用于比较不同海拔高度的研究结果。多元线性、逻辑回归和分类树分析将用于计算高海拔环境下各种因素（如海拔、年龄和体力活动）对骨骼肌系统的影响。最后，将计算出不同海拔地区成年人肌少症的暂定诊断切点。
该研究已获得每个研究中心机构研究伦理委员会的批准（主要中心编号：KHLL2021-KY056）。结果将通过科学会议和同行评议出版物以及与利益相关者的会议进行传播。
http://www.chictr.org.cn/index.aspx，标识符 ChiCTR2100052153。
