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微区毛发分析：法庭毒物学中的详细程序和应用。

Micro-segmental hair analysis: detailed procedures and applications in forensic toxicology.

机构信息

National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa, Chiba, 277-0882, Japan.

出版信息

Forensic Toxicol. 2022 Jul;40(2):215-233. doi: 10.1007/s11419-022-00619-9. Epub 2022 Mar 21.

DOI:10.1007/s11419-022-00619-9
PMID:36454411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9715473/
Abstract

PURPOSE

Since the 1980s, the detection sensitivity of mass spectrometers has increased by improving the analysis of drugs in hair. Accordingly, the number of hair strands required for the analysis has decreased. The length of the hair segment used in the analysis has also shortened. In 2016, micro-segmental hair analysis (MSA), which cuts a single hair strand at a 0.4-mm interval corresponding to a hair growth length of approximately one day, was developed. The advantage of MSA is that the analytical results provide powerful evidence of drug use in the investigation of drug-related crimes and detailed information about the mechanism of drug uptake into hair. This review article focuses on the MSA technique and its applications in forensic toxicology.

METHODS

Multiple databases, such as SciFinder, PubMed, and Google, were utilized to collect relevant reports referring to MSA and drug analysis in hair. The experiences of our research group on the MSA were also included in this review.

RESULTS

The analytical results provide a detailed drug distribution profile in a hair strand, which is useful for examining the mechanism of drug uptake into hair in detail. Additionally, the analytical method has been used for various scenarios in forensic toxicology, such as the estimation of days of drug consumption and death.

CONCLUSIONS

The detailed procedures are summarized so that beginners can use the analytical method in their laboratories. Moreover, some application examples are presented, and the limitations of the current analytical method and future perspectives are described.

摘要

目的

自 20 世纪 80 年代以来，通过改进毛发中药物的分析，质谱仪的检测灵敏度得到了提高。因此，分析所需的毛发数量减少了。用于分析的毛发段的长度也缩短了。2016 年，开发了微分段毛发分析（MSA），它以对应于大约一天的头发生长长度的 0.4 毫米的间隔切割单根毛发，将毛发切成 0.4 毫米的间隔。MSA 的优点是分析结果为毒品相关犯罪调查中的药物使用提供了有力的证据，并提供了有关药物摄取到毛发中的机制的详细信息。本文综述了 MSA 技术及其在法医毒理学中的应用。

方法

利用 SciFinder、PubMed 和 Google 等多个数据库收集有关 MSA 和毛发中药物分析的相关报告。本文还包括了我们研究小组在 MSA 方面的经验。

结果

分析结果提供了毛发中药物的详细分布情况，有助于详细检查药物摄取到毛发中的机制。此外，该分析方法已用于法医毒理学中的各种情况，例如估计药物使用天数和死亡时间。

结论

总结了详细的程序，以便初学者可以在实验室中使用该分析方法。此外，还提供了一些应用示例，并描述了当前分析方法的局限性和未来展望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5658/9715473/bd1f0bc5ead0/11419_2022_619_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5658/9715473/6734e046a6b4/11419_2022_619_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5658/9715473/bd1f0bc5ead0/11419_2022_619_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5658/9715473/6734e046a6b4/11419_2022_619_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5658/9715473/351dcfc8a02a/11419_2022_619_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5658/9715473/eed7d870cd2f/11419_2022_619_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5658/9715473/1b5653032dd2/11419_2022_619_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5658/9715473/e102c8770f8f/11419_2022_619_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5658/9715473/5940e0d2c16c/11419_2022_619_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5658/9715473/e3a7d7732a93/11419_2022_619_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5658/9715473/bd1f0bc5ead0/11419_2022_619_Fig8_HTML.jpg

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