Sigdel Prem Raj, Mahaseth Navin, Pokharel Bharat Mani, Thapa Jeevan, Jalan Aditya, Gharti Binod Babu, Pokharel Gyan Prasad, Pandey Greta, Nepal Umesh, Lamichhane Nirmal
Department of Uro-Oncology, BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal.
Department of Community Health Sciences, Patan Academy of Health Sciences, Patan, Nepal.
Int Urol Nephrol. 2023 Mar;55(3):589-596. doi: 10.1007/s11255-022-03427-7. Epub 2022 Dec 1.
This study was done to find out the clinicopathological characteristics of carcinoma penis in Nepali population and to evaluate various risk factors that predict its inguinal lymph node metastasis.
A retrospective cross-sectional study was carried out at the Urology Unit, Department of Surgical Oncology at BP Koirala Memorial Cancer Hospital, Bharatpur, Nepal. Case notes of biopsy-proven penile cancer, from January 2012 to December 2021, who underwent some form of surgical intervention were included.
A total of 380 patients were included in the study. The mean age of the patients was 55.92 ± 13.81 years. At presentation, 78.5% had clinically node-positive disease. The most common treatment for the primary tumor was partial amputation of the penis (74.2%). Bilateral inguinal lymph node dissections were done in 370 cases. The most common histology was the usual SCC in 94.2% of cases and 69% were well differentiated. T3 was the most common staging in 49.4% cases. Pathologically nodal negative status was found in 58% cases. In univariate analysis, factors like duration of symptoms (≥ 6 months), high-risk histopathology (basaloid/sarcomatoid variant), increased T-stage, poorly differentiated tumor, and the presence of PNI or LVI were significantly associated with lymph node metastasis.
Penile cancer is a common cancer in developing countries such as Nepal. The majority of the patients present late. Early recognition and prompt treatment are required to improve the overall outcome.
本研究旨在了解尼泊尔人群阴茎癌的临床病理特征，并评估预测其腹股沟淋巴结转移的各种危险因素。
在尼泊尔巴拉特布尔BP柯伊拉腊纪念癌症医院外科肿瘤学系泌尿外科进行了一项回顾性横断面研究。纳入了2012年1月至2021年12月期间经活检证实为阴茎癌且接受了某种形式手术干预的病例记录。
本研究共纳入380例患者。患者的平均年龄为55.92±13.81岁。就诊时，78.5%的患者临床淋巴结阳性。原发性肿瘤最常见的治疗方法是阴茎部分切除术（74.2%）。370例患者进行了双侧腹股沟淋巴结清扫术。最常见的组织学类型是普通鳞状细胞癌，占94.2%的病例，69%为高分化。T3是最常见的分期，占49.4%的病例。病理检查发现58%的病例淋巴结阴性。在单因素分析中，症状持续时间（≥6个月）、高危组织病理学（基底样/肉瘤样变体）、T分期增加、肿瘤分化差以及存在神经侵犯或淋巴管侵犯等因素与淋巴结转移显著相关。
阴茎癌在尼泊尔等发展中国家是一种常见癌症。大多数患者就诊时已处于晚期。需要早期识别和及时治疗以改善总体预后。
