从兔尿中分离出的δ1-四氢大麻酚的酸性代谢物。

Acidic metabolites of delta1-tetrahydrocannabinol isolated from rabbit urine.

作者信息

Nordqvist M, Lindgren J E, Agurell S

出版信息

J Pharm Pharmacol. 1979 Apr;31(4):231-7. doi: 10.1111/j.2042-7158.1979.tb13485.x.

DOI:10.1111/j.2042-7158.1979.tb13485.x

Abstract

The in vivo metabolism of delta1-tetrahydrocannabinol (delta1-THC) was investigated in the rabbit after i.v. administration. Thirteen acidic metabolites were isolated from rabbit urine and identified by gas chromatography-mass spectrometry and by proton magnetic resonance spectroscopy. One additional metabolite was tentatively identified. All but three were new metabolites and all but one were oxidized in the pentyl side chain. The metabolites included dicarboxylic acids, monocarboxylic acids and mono- or dihydroxylated derivatives thereof. However, the dicarboxylic acid metabolites were the most prominent.

摘要

静脉注射给药后，在兔体内研究了δ1-四氢大麻酚（δ1-THC）的代谢情况。从兔尿中分离出13种酸性代谢物，并通过气相色谱-质谱联用和质子磁共振光谱进行鉴定。另外一种代谢物进行了初步鉴定。除三种外，其余均为新的代谢物，除一种外，其余均在戊基侧链上被氧化。代谢物包括二羧酸、单羧酸及其单羟基或二羟基化衍生物。然而，二羧酸代谢物最为突出。