State Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin 301617, China.
Int J Mol Sci. 2023 Dec 16;24(24):17538. doi: 10.3390/ijms242417538.
Ulcerative colitis, an immune-mediated inflammatory disease of the gastrointestinal tract, places a significant financial burden on patients and the healthcare system. Recently, reviews of the pomegranate and the abundant medicinal applications of its ellagitannins, as well as its pharmacological action, phytochemicals, metabolism, and pharmacokinetics, have been completed. However, summaries on their anti-ulcerative colitis effects are lacking. Numerous preclinical animal investigations and clinical human trial reports demonstrated the specific therapeutic effects of pomegranate and the effect of its ellagitannins against ulcerative colitis. According to the literature collected by Sci-finder and PubMed databases over the past 20 years, this is the first review that has compiled references regarding how the rich ellagitannins found in pomegranate have altered the ulcerative colitis. It was suggested that the various parts of pomegranates and their rich ellagitannins (especially their primary components, punicalagin, and ellagic acid) can inhibit oxidant and inflammatory processes, regulate the intestinal barrier and flora, and provide an anti-ulcerative colitis resource through dietary management.
溃疡性结肠炎是一种胃肠道免疫介导的炎症性疾病，给患者和医疗体系带来了巨大的经济负担。最近，有关石榴及其丰富的鞣花单宁的药用应用、药理作用、植物化学物质、代谢和药代动力学的综述已经完成。然而，关于其抗溃疡性结肠炎作用的综述却很少。大量的临床前动物研究和临床人体试验报告表明，石榴具有特定的治疗溃疡性结肠炎的作用，其鞣花单宁也具有这种作用。根据过去 20 年在 Sci-finder 和 PubMed 数据库中收集的文献，这是第一篇综述，它汇编了关于石榴中丰富的鞣花单宁如何改变溃疡性结肠炎的参考文献。研究表明，石榴的各个部位及其丰富的鞣花单宁（特别是其主要成分鞣花酸和安石榴苷）可以抑制氧化应激和炎症过程，调节肠道屏障和菌群，通过饮食管理为抗溃疡性结肠炎提供资源。
