Venugopal Akhil, Ruiz-Perez Lorena, Swamynathan K, Kulkarni Chidambar, Calò Annalisa, Kumar Mohit
Institute for Bioengineering of Catalonia (IBEC), Calle Baldiri Reixac 10-12, 08028, Barcelona, Spain.
Soft Condensed Matter, Raman Research Institute, C. V. Raman Avenue, Sadashivanagar, Bangalore-560080, India.
Angew Chem Int Ed Engl. 2023 Feb 13;62(8):e202208681. doi: 10.1002/anie.202208681. Epub 2022 Dec 22.
Supramolecular systems chemistry has been an area of active research to develop nanomaterials with life-like functions. Progress in systems chemistry relies on our ability to probe the nanostructure formation in solution. Often visualizing the dynamics of nanostructures which transform over time is a formidable challenge. This necessitates a paradigm shift from dry sample imaging towards solution-based techniques. We review the application of state-of-the-art techniques for real-time, in situ visualization of dynamic self-assembly processes. We present how solution-based techniques namely optical super-resolution microscopy, solution-state atomic force microscopy, liquid-phase transmission electron microscopy, molecular dynamics simulations and other emerging techniques are revolutionizing our understanding of active and adaptive nanomaterials with life-like functions. This Review provides the visualization toolbox and futuristic vision to tap the potential of dynamic nanomaterials.
超分子体系化学一直是一个积极开展研究以开发具有类生命功能的纳米材料的领域。体系化学的进展依赖于我们探测溶液中纳米结构形成的能力。通常，可视化随时间变化的纳米结构动力学是一项艰巨的挑战。这就需要从干样品成像向基于溶液的技术进行范式转变。我们综述了用于动态自组装过程实时、原位可视化的前沿技术的应用。我们展示了基于溶液的技术，即光学超分辨率显微镜、溶液态原子力显微镜、液相透射电子显微镜、分子动力学模拟以及其他新兴技术，如何正在彻底改变我们对具有类生命功能的活性和自适应纳米材料的理解。本综述提供了可视化工具箱以及挖掘动态纳米材料潜力的未来愿景。
