新冠疫情对青少年心理健康和大脑发育的影响：对纵向数据分析的启示
Effects of the COVID-19 Pandemic on Mental Health and Brain Maturation in Adolescents: Implications for Analyzing Longitudinal Data.
作者信息
Gotlib Ian H, Miller Jonas G, Borchers Lauren R, Coury Sache M, Costello Lauren A, Garcia Jordan M, Ho Tiffany C
机构信息
Department of Psychology, Stanford University.
Department of Psychiatry and Weill Institute for Neurosciences, University of California, San Francisco.
出版信息
Biol Psychiatry Glob Open Sci. 2022 Dec 1;3(4):912-8. doi: 10.1016/j.bpsgos.2022.11.002.
BACKGROUND
The COVID-19 pandemic has caused significant stress and disruption for young people, likely leading to alterations in their mental health and neurodevelopment. In this context, it is not clear whether youth who lived through the pandemic and its shutdowns are comparable psychobiologically to their age- and sex-matched peers assessed before the pandemic. This question is particularly important for researchers who are analyzing longitudinal data that span the pandemic.
METHODS
In this study we compared carefully matched youth assessed before the pandemic (81) and after the pandemic-related shutdowns ended (82).
RESULTS
We found that youth assessed after the pandemic shutdowns had more severe internalizing mental health problems, reduced cortical thickness, larger hippocampal and amygdala volume, and more advanced brain age.
CONCLUSIONS
Thus, not only does the COVID-19 pandemic appear to have led to poorer mental health and accelerated brain aging in adolescents, but it also poses significant challenges to researchers analyzing data from longitudinal studies of normative development that were interrupted by the pandemic.
背景
新冠疫情给年轻人带来了巨大压力和干扰，可能导致他们的心理健康和神经发育发生改变。在这种情况下，经历过疫情及其封锁措施的年轻人在心理生物学方面是否与疫情前评估的年龄和性别匹配的同龄人相当尚不清楚。对于正在分析跨越疫情期间的纵向数据的研究人员来说，这个问题尤为重要。
方法
在本研究中，我们对疫情前评估的81名年轻人和疫情相关封锁结束后评估的82名年轻人进行了仔细匹配比较。
结果
我们发现，疫情封锁结束后评估的年轻人有更严重的内化心理健康问题、皮层厚度减小、海马体和杏仁核体积增大以及脑龄更超前。
结论
因此，新冠疫情似乎不仅导致青少年心理健康状况变差和大脑加速衰老，还给分析被疫情中断的规范发育纵向研究数据的研究人员带来了重大挑战。
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