Ko B-J, Kim S M, Park K H, Park H S, Mantzoros C S
1] Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA [2] Department of Family Medicine, College of Medicine, Korea University, Seoul, Korea.
Department of Family Medicine, College of Medicine, Korea University, Seoul, Korea.
Int J Obes (Lond). 2014 Dec;38(12):1497-502. doi: 10.1038/ijo.2014.45. Epub 2014 Mar 18.
BACKGROUND/OBJECTIVES: Circulating selenoprotein P (SeP), fibroblast growth factor (FGF) 21 and FGF23 have been associated with metabolic syndrome (MetS) in adults but not in children. We sought to evaluate the association among SeP, FGF21, FGF23 and MetS in young children.
SUBJECTS/METHODS: A cross-sectional study conducted during a school health examination on 210 children aged 9 years. We measured serum SeP, FGF21 and FGF23 levels, and assessed anthropometric and cardiometabolic variables. MetS was defined as the presence of ⩾3 of the following five criteria: high blood pressure, low high-density lipoprotein cholesterol (HDL-C), high triglyceride, high fasting glucose and abdominal obesity.
SeP was correlated positively with HDL-C and negatively with body mass index, waist circumference (WC), blood pressure, transaminases, triglyceride and homeostasis model assessment of insulin resistance (HOMA-IR). FGF21 was directly correlated with WC, triglyceride and HOMA-IR, and FGF23 was inversely correlated with fasting glucose and alanine aminotransferase. Children with MetS had lower SeP and FGF23 levels and higher HOMA-IR than children without MetS. The highest tertile of SeP had decreased odds for MetS (odds ratio 0.05, 95% confidence interval (CI) 0.00-0.96, P for trend=0.042), whereas FGF21 and FGF23 did not relate to the risk for MetS after controlling for confounders.
Elevated SeP concentrations are independently associated with a reduced risk of MetS in children. The associations between FGF21, FGF23 and metabolic parameters are not of comparable significance.
背景/目的：循环硒蛋白P（SeP）、成纤维细胞生长因子（FGF）21和FGF23与成人代谢综合征（MetS）有关，但与儿童无关。我们试图评估幼儿中SeP、FGF21、FGF23与MetS之间的关联。
对象/方法：在一次学校健康检查中对210名9岁儿童进行了横断面研究。我们测量了血清SeP、FGF21和FGF23水平，并评估了人体测量和心脏代谢变量。MetS被定义为符合以下五项标准中的至少三项：高血压、低高密度脂蛋白胆固醇（HDL-C）、高甘油三酯、高空腹血糖和腹部肥胖。
SeP与HDL-C呈正相关，与体重指数、腰围（WC）、血压、转氨酶、甘油三酯和胰岛素抵抗稳态模型评估（HOMA-IR）呈负相关。FGF21与WC（腰围）、甘油三酯和HOMA-IR直接相关，FGF23与空腹血糖和丙氨酸转氨酶呈负相关。患有MetS的儿童比未患MetS的儿童SeP和FGF23水平更低，HOMA-IR更高。SeP最高三分位数组患MetS的几率降低（优势比0.05，95%置信区间（CI）0.00 - 0.96，趋势P值 = 0.042），而在控制混杂因素后，FGF21和FGF23与MetS风险无关。
儿童中SeP浓度升高与MetS风险降低独立相关。FGF21、FGF23与代谢参数之间的关联没有类似的显著意义。
