自然杀伤细胞在免疫检查点阻断中的新兴作用。
The Emerging Role of NK Cells in Immune Checkpoint Blockade.
作者信息
Martinez-Perez Alejandra, Aguilar-Garcia Candelaria, Gonzalez Segundo
机构信息
Department of Functional Biology, Immunology, Universidad de Oviedo, 33006 Oviedo, Spain.
Instituto Universitario de Oncología del Principado de Asturias (IUOPA), 33006 Oviedo, Spain.
出版信息
Cancers (Basel). 2022 Dec 6;14(23):6005. doi: 10.3390/cancers14236005.
Abstract
Natural killer (NK) cells are innate cytotoxic immune cells that play a fundamental role in anti-tumor immunity, particularly in hematological cancers, disseminated cancers, and metastasis [...].
摘要
自然杀伤（NK）细胞是先天性细胞毒性免疫细胞，在抗肿瘤免疫中发挥着重要作用，尤其是在血液系统癌症、播散性癌症和转移瘤中[……]。
相似文献
1
The Emerging Role of NK Cells in Immune Checkpoint Blockade.自然杀伤细胞在免疫检查点阻断中的新兴作用。
Cancers (Basel). 2022 Dec 6;14(23):6005. doi: 10.3390/cancers14236005.
2
Targeting Checkpoint Receptors and Molecules for Therapeutic Modulation of Natural Killer Cells.针对免疫检查点受体和分子的自然杀伤细胞治疗调节。
Front Immunol. 2018 Sep 10;9:2041. doi: 10.3389/fimmu.2018.02041. eCollection 2018.
3
Natural Killer Cells: The Linchpin for Successful Cancer Immunotherapy.自然杀伤细胞：癌症免疫治疗成功的关键。
Front Immunol. 2021 Apr 28;12:679117. doi: 10.3389/fimmu.2021.679117. eCollection 2021.
4
Targeting immune checkpoints in hematological malignancies.靶向血液系统恶性肿瘤的免疫检查点。
J Hematol Oncol. 2020 Aug 12;13(1):111. doi: 10.1186/s13045-020-00947-6.
5
NK Cell Dysfunction and Checkpoint Immunotherapy.自然杀伤细胞功能障碍与检查点免疫治疗。
Front Immunol. 2019 Aug 21;10:1999. doi: 10.3389/fimmu.2019.01999. eCollection 2019.
6
Blockade of novel immune checkpoints and new therapeutic combinations to boost antitumor immunity.阻断新型免疫检查点与新的治疗组合以增强抗肿瘤免疫。
J Exp Clin Cancer Res. 2022 Feb 14;41(1):62. doi: 10.1186/s13046-022-02264-x.
7
The Rise of NK Cell Checkpoints as Promising Therapeutic Targets in Cancer Immunotherapy.自然杀伤细胞检查点在癌症免疫治疗中作为有前途的治疗靶点的兴起。
Front Immunol. 2019 Oct 17;10:2354. doi: 10.3389/fimmu.2019.02354. eCollection 2019.
8
Combination blockade of KLRG1 and PD-1 promotes immune control of local and disseminated cancers.阻断 KLRG1 和 PD-1 可促进局部和转移性肿瘤的免疫控制。
Oncoimmunology. 2021 Jun 15;10(1):1933808. doi: 10.1080/2162402X.2021.1933808.
9
Plasticity of NK cells in Cancer.NK 细胞在癌症中的可塑性。
Front Immunol. 2022 May 10;13:888313. doi: 10.3389/fimmu.2022.888313. eCollection 2022.
10
Blockade of checkpoint receptor PVRIG unleashes anti-tumor immunity of NK cells in murine and human solid tumors.阻断检查点受体 PVRIG 可释放 NK 细胞在鼠类和人类实体肿瘤中的抗肿瘤免疫。
J Hematol Oncol. 2021 Jun 26;14(1):100. doi: 10.1186/s13045-021-01112-3.
引用本文的文献
1
Multi-omics reveal immune microenvironment alterations in multiple myeloma and its precursor stages.多组学揭示多发性骨髓瘤及其前体阶段的免疫微环境改变。
Blood Cancer J. 2024 Nov 6;14(1):194. doi: 10.1038/s41408-024-01172-x.
2
Targeting oral tumor microenvironment for effective therapy.靶向口腔肿瘤微环境以实现有效治疗。
Cancer Cell Int. 2023 May 23;23(1):101. doi: 10.1186/s12935-023-02943-5.
本文引用的文献
1
LAG-3 Blockade with Relatlimab (BMS-986016) Restores Anti-Leukemic Responses in Chronic Lymphocytic Leukemia.使用瑞利单抗（BMS-986016）阻断LAG-3可恢复慢性淋巴细胞白血病的抗白血病反应。
Cancers (Basel). 2021 Apr 27;13(9):2112. doi: 10.3390/cancers13092112.
2
BTLA/HVEM Axis Induces NK Cell Immunosuppression and Poor Outcome in Chronic Lymphocytic Leukemia.BTLA/HVEM轴诱导慢性淋巴细胞白血病中的自然杀伤细胞免疫抑制及不良预后。
Cancers (Basel). 2021 Apr 7;13(8):1766. doi: 10.3390/cancers13081766.
3
The Immune Checkpoint PD-1 in Natural Killer Cells: Expression, Function and Targeting in Tumour Immunotherapy.自然杀伤细胞中的免疫检查点PD-1：在肿瘤免疫治疗中的表达、功能及靶向作用
Cancers (Basel). 2020 Nov 6;12(11):3285. doi: 10.3390/cancers12113285.
4
Mechanisms of NK cell dysfunction in the tumor microenvironment and current clinical approaches to harness NK cell potential for immunotherapy.肿瘤微环境中 NK 细胞功能障碍的机制及当前利用 NK 细胞潜力进行免疫治疗的临床方法。
J Leukoc Biol. 2021 Jun;109(6):1071-1088. doi: 10.1002/JLB.5MR0920-198RR. Epub 2020 Sep 29.
5
Revisiting the PD-1 pathway.重新审视PD-1通路。
Sci Adv. 2020 Sep 18;6(38). doi: 10.1126/sciadv.abd2712. Print 2020 Sep.
6
Glucocorticoids and the cytokines IL-12, IL-15, and IL-18 present in the tumor microenvironment induce PD-1 expression on human natural killer cells.糖皮质激素和肿瘤微环境中存在的细胞因子 IL-12、IL-15 和 IL-18 诱导人自然杀伤细胞表达 PD-1。
J Allergy Clin Immunol. 2021 Jan;147(1):349-360. doi: 10.1016/j.jaci.2020.04.044. Epub 2020 May 14.
7
PD-1 natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade.PD-1/PD-L1 阻断可激活人非小细胞肺癌中的 PD-1 自然杀伤细胞。
Cancer Immunol Immunother. 2020 Aug;69(8):1505-1517. doi: 10.1007/s00262-020-02558-z. Epub 2020 Apr 15.
8
Mechanisms of Resistance to NK Cell Immunotherapy.对自然杀伤细胞免疫疗法的耐药机制。
Cancers (Basel). 2020 Apr 7;12(4):893. doi: 10.3390/cancers12040893.
9
NK Cells in the Treatment of Hematological Malignancies.自然杀伤细胞在血液系统恶性肿瘤治疗中的应用
J Clin Med. 2019 Sep 27;8(10):1557. doi: 10.3390/jcm8101557.
10
The Mechanism of Anti-PD-L1 Antibody Efficacy against PD-L1-Negative Tumors Identifies NK Cells Expressing PD-L1 as a Cytolytic Effector.抗 PD-L1 抗体对 PD-L1 阴性肿瘤疗效的机制将 PD-L1 表达的 NK 细胞鉴定为细胞溶解效应细胞。
Cancer Discov. 2019 Oct;9(10):1422-1437. doi: 10.1158/2159-8290.CD-18-1259. Epub 2019 Jul 24.
Zotero 插件