Division of Child and Adolescent Psychiatry & Division of Developmental and Behavioral Pediatrics, China Medical University Children's Hospital, Taichung 404327, Taiwan.
School of Post Baccalaureate Chinese Medicine, China Medical University, Taichung 406040, Taiwan.
Int J Environ Res Public Health. 2022 Dec 5;19(23):16277. doi: 10.3390/ijerph192316277.
Background: Despite known association of internet addiction with a reduced brain volume and abnormal connectivity, the impact of excessive smartphone use remains unclear. Methods: PubMed, Embase, ClinicalTrial.gov, and Web of Science databases were systematically searched from inception to July 2022 using appropriate keywords for observational studies comparing differences in brain volumes and activations between excessive smartphone users and individuals with regular use by magnetic resonance imaging. Results: Of the 11 eligible studies retrieved from 6993 articles initially screened, seven and six evaluated brain volumes and activations, respectively. The former enrolled 421 participants (165 excessive smartphone users vs. 256 controls), while the latter recruited 276 subjects with 139 excessive smartphone users. The results demonstrated a smaller brain volume in excessive smartphone users compared to the controls (g = −0.55, p < 0.001), especially in subcortical regions (p < 0.001). Besides, the impact was more pronounced in adolescents than in adults (p < 0.001). Regression analysis revealed a significant positive association between impulsivity and volume reduction. Regarding altered activations, the convergences of foci in the declive of the posterior lobe of cerebellum, the lingual gyrus, and the middle frontal gyrus were noted. Conclusions: Our findings demonstrated a potential association of excessive smartphone use with a reduced brain volume and altered activations.
尽管已知网瘾与脑容量减少和连接异常有关，但过度使用智能手机的影响仍不清楚。
我们系统地检索了 PubMed、Embase、ClinicalTrials.gov 和 Web of Science 数据库，从建库到 2022 年 7 月，使用适当的关键词搜索了比较过度使用智能手机者和正常使用智能手机者之间脑容量和激活差异的观察性研究。
在最初筛选的 6993 篇文章中，有 11 项符合条件的研究被纳入，其中 7 项评估了脑容量，6 项评估了脑激活。前者纳入了 421 名参与者（165 名过度使用智能手机者与 256 名对照者），后者招募了 276 名参与者，其中 139 名过度使用智能手机者。结果表明，与对照组相比，过度使用智能手机者的脑容量较小（g=-0.55，p<0.001），特别是在皮质下区域（p<0.001）。此外，这种影响在青少年中比在成年人中更为明显（p<0.001）。回归分析显示，冲动性与体积减少之间存在显著的正相关关系。至于改变的激活，在后叶小脑、舌回和中额回的下降处发现了焦点的汇聚。
我们的研究结果表明，过度使用智能手机可能与脑容量减少和激活改变有关。
