Hoogendijk Emiel O, Dent Elsa
Department of General Practice, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Department of Epidemiology and Data Science, Amsterdam UMC, location Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Ann Geriatr Med Res. 2022 Dec;26(4):289-295. doi: 10.4235/agmr.22.0148. Epub 2022 Dec 12.
Frailty is an age-related clinical state associated with deterioration across multiple physiological systems and a leading cause of morbidity and mortality later in life. To understand how frailty develops and what causes its progression, longitudinal data with repeated frailty measurements are required. This review summarizes evidence from longitudinal studies on frailty trajectories, transitions, and trends. We identified several consistent findings: frailty increases with aging and is a dynamic condition, and more recent generations of older adults have higher frailty levels. These findings have both clinical and public health relevance, including the provision of healthcare and aged care services in the coming years. Further studies are required, particularly those conducted in low- and middle-income countries and those investigating factors associated with changes in frailty. The latter may help develop better-targeted interventions to reverse or slow the progression of frailty.
衰弱是一种与年龄相关的临床状态，与多个生理系统的衰退相关，是晚年发病和死亡的主要原因。为了了解衰弱如何发展以及导致其进展的原因，需要有重复衰弱测量的纵向数据。本综述总结了关于衰弱轨迹、转变和趋势的纵向研究证据。我们确定了几个一致的发现：衰弱随年龄增长而增加，且是一种动态状况，最近几代老年人的衰弱水平更高。这些发现具有临床和公共卫生意义，包括未来几年医疗保健和老年护理服务的提供。需要进一步开展研究，特别是在低收入和中等收入国家进行的研究，以及调查与衰弱变化相关因素的研究。后者可能有助于制定更有针对性的干预措施，以逆转或减缓衰弱的进展。
