Ling Xuebin, Jie Wei, Qin Xue, Zhang Shuya, Shi Kaijia, Li Tianfa, Guo Junli
Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province, Department of Cardiovascular Medicine of the First Affiliated Hospital, Hainan Medical University, Haikou, China.
Key Laboratory of Emergency and Trauma of Ministry of Education, Hainan Medical University, Haikou, China.
Front Cardiovasc Med. 2022 Nov 25;9:1063683. doi: 10.3389/fcvm.2022.1063683. eCollection 2022.
Abdominal aortic aneurysm (AAA) is an inflammatory vascular disease with high disability and mortality. Its susceptible risk factors include old age, being male, smoking, hypertension, and aortic atherosclerosis. With the improvement of screening techniques, AAA incidence and number of deaths caused by aneurysm rupture increase annually, attracting much clinical attention. Due to the lack of non-invasive treatment, early detection and development of novel treatment of AAA is an urgent clinical concern. The pathophysiology and progression of AAA are characterized by inflammatory destruction. The gut microbiota is an "invisible organ" that directly or indirectly affects the vascular wall inflammatory cell infiltration manifested with enhanced arterial wall gut microbiota and metabolites, which plays an important role in the formation and progression of AAA. As such, the gut microbiome may become an important risk factor for AAA. This review summarizes the direct and indirect effects of the gut microbiome on the pathogenesis of AAA and highlights the gut microbiome-mediated inflammatory responses and discoveries of relevant therapeutic targets that may help manage the development and rupture of AAA.
腹主动脉瘤（AAA）是一种具有高致残率和死亡率的炎症性血管疾病。其易感风险因素包括老年、男性、吸烟、高血压和主动脉粥样硬化。随着筛查技术的改进，AAA的发病率和由动脉瘤破裂导致的死亡人数逐年增加，引起了临床的广泛关注。由于缺乏非侵入性治疗方法，早期发现并开发AAA的新型治疗方法是临床亟待解决的问题。AAA的病理生理学和进展以炎症破坏为特征。肠道微生物群是一个“无形的器官”，它直接或间接影响血管壁炎症细胞浸润，表现为动脉壁肠道微生物群及其代谢产物增加，这在AAA的形成和进展中起重要作用。因此，肠道微生物群可能成为AAA的一个重要风险因素。本文综述了肠道微生物群对AAA发病机制的直接和间接影响，并强调了肠道微生物群介导的炎症反应以及相关治疗靶点的发现，这些可能有助于控制AAA的发展和破裂。
