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Aducanumab and Its Effects on Tau Pathology: Is This the Turning Point of Amyloid Hypothesis?阿杜卡奴单抗及其对 Tau 病理学的影响:这是淀粉样假说的转折点吗?
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The neuroprotective effects of icariin on ageing, various neurological, neuropsychiatric disorders, and brain injury induced by radiation exposure.朝藿定对衰老、各种神经、神经精神疾病以及辐射暴露引起的脑损伤的神经保护作用。
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Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis.红景天苷通过靶向NLRP3炎性小体介导的细胞焦亡改善阿尔茨海默病。
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Dendrobium nobile Lindl. Alkaloids Ameliorate Aβ25-35-Induced Synaptic Deficits by Targeting Wnt/β-Catenin Pathway in Alzheimer's Disease Models.铁皮石斛生物碱通过靶向阿尔茨海默病模型中的 Wnt/β-连环蛋白通路改善 Aβ25-35 诱导的突触缺陷。
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中医药治疗阿尔茨海默病及相关痴呆症的研究进展

Research progress in traditional Chinese medicine in the treatment of Alzheimer's disease and related dementias.

作者信息

Tan Wanying, Qi Lingjun, Hu Xiaoyu, Tan Zhenghuai

机构信息

Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Sichuan Academy of Traditional Chinese Medicine, Chengdu, China.

出版信息

Front Pharmacol. 2022 Nov 24;13:921794. doi: 10.3389/fphar.2022.921794. eCollection 2022.

DOI:10.3389/fphar.2022.921794
PMID:36506569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9729772/
Abstract

Alzheimer's disease (AD) is the world's leading cause of dementia and has become a huge economic burden on nations and families. However, the exact etiology of AD is still unknown, and there are no efficient medicines or methods to prevent the deterioration of cognition. Traditional Chinese medicine (TCM) has made important contributions in the battle against AD based on the characteristics of multiple targets of TCM. This study reviewed the treatment strategies and new discoveries of traditional Chinese medicine in current research, which may be beneficial to new drug researchers.

摘要

阿尔茨海默病(AD)是全球痴呆症的主要病因,已给各国和家庭带来巨大经济负担。然而,AD的确切病因仍不清楚,也没有有效的药物或方法来防止认知功能恶化。基于中药多靶点的特点,中药在对抗AD的战斗中做出了重要贡献。本研究综述了当前研究中中药的治疗策略和新发现,这可能对新药研究人员有益。