Department of Physiology, University of Alberta, Edmonton, AB, Canada.
Front Neural Circuits. 2022 Nov 24;16:1076766. doi: 10.3389/fncir.2022.1076766. eCollection 2022.
In the past two decades we have learned an enormous amount of information regarding the identity of functional components of the neural circuitry responsible for generating locomotor activity in mammals. Molecular techniques, combined with classic electrophysiological and anatomical approaches, have resulted in the identification of a handful of classes of genetically defined interneuronal populations, and a delineation of the specific function of many of these during stepping. What lags behind at this point is a clear picture of the synaptic connectivity of each population, this information is key if we are to understand how the interneuronal components that are responsible for locomotor activity work together to form a functional circuit. In this mini review I will summarize what is, and what is not, known regarding the synaptic connectivity of each genetically defined interneuronal population that is involved in locomotion.
在过去的二十年中，我们已经了解了大量有关负责产生哺乳动物运动活动的神经回路功能成分的信息。分子技术与经典电生理学和解剖学方法相结合，已经确定了少数几类具有遗传定义的神经元群体，并且阐明了这些神经元群体在行走过程中的特定功能。目前尚不清楚的是每个神经元群体的突触连接，而如果我们要了解负责运动活动的神经元组件如何协同工作形成功能性回路，那么这种信息是至关重要的。在这个小型综述中，我将总结有关涉及运动的每个具有遗传定义的神经元群体的突触连接的已知和未知情况。
