Hao Jianan, Wang Yichao, Huo Lijing, Sun Tiantian, Zhen Yunfeng, Gao Zhe, Chen Shuchun, Ren Luping
Endocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, 050000, People's Republic of China.
Graduate School of Hebei Medical University, Shijiazhuang, Hebei, 050000, People's Republic of China.
Int J Gen Med. 2022 Dec 7;15:8539-8546. doi: 10.2147/IJGM.S385513. eCollection 2022.
We aimed to examine the association between bone morphogenetic protein-9 (BMP-9) and type 2 diabetes mellitus (T2DM) in conjunction with non-alcoholic fatty liver disease (NAFLD) and insulin resistance (IR) and to identify evidence supporting the potential role of BMP-9 in the clinical prevention and treatment of T2DM in conjunction with NAFLD.
One hundred and twenty subjects were included in this study. We sorted all of the subjects into four groups of equal size (n=30 each). A trained expert assessed the height, weight, systolic blood pressure (SBP), and diastolic blood pressure (DBP) of the subjects and computed the body mass index (BMI). All subjects had their fasting blood glucose (FBG), fasting insulin (FINS), serum BMP-9, and biochemical indices assessed.
Significant variations were observed in BMI, SBP, DBP, ALT, TC, TG, HDL-C, LDL-C, ApoB, FBG, FINS, HOMA-IR, and serum BMP-9 among the four groups (P<0.05). The level of serum BMP-9 was positively correlated with HDL-C, while the level of serum BMP-9 was negatively correlated with BMI, SBP, DBP, ALT, TC, TG, LDL-C, FBG, FINS, and HOMA-IR. Multiple stepwise regression analyses revealed that FINS, LDL-C, HDL-C, and BMI were independent factors impacting serum BMP-9 levels (P<0.05). Logistic regression analyses revealed that BMP-9 was a protective factor for T2DM paired with NAFLD, while HOMA-IR was a risk factor.
Serum BMP-9 levels are significantly lower in the T2DM+NAFLD group when compared to other groups, and BMP-9 is an independent risk factor for T2DM paired with NAFLD.
我们旨在研究骨形态发生蛋白-9（BMP-9）与2型糖尿病（T2DM）、非酒精性脂肪性肝病（NAFLD）及胰岛素抵抗（IR）之间的关联，并确定支持BMP-9在T2DM合并NAFLD临床防治中潜在作用的证据。
本研究纳入120名受试者。我们将所有受试者平均分为四组（每组n = 30）。一名经过培训的专家对受试者的身高、体重、收缩压（SBP）和舒张压（DBP）进行评估，并计算体重指数（BMI）。所有受试者均接受空腹血糖（FBG）、空腹胰岛素（FINS）、血清BMP-9及生化指标检测。
四组受试者的BMI、SBP、DBP、谷丙转氨酶（ALT）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白B（ApoB）、FBG、FINS、稳态模型评估的胰岛素抵抗指数（HOMA-IR）及血清BMP-9存在显著差异（P < 0.05）。血清BMP-9水平与HDL-C呈正相关，而与BMI、SBP、DBP、ALT、TC、TG、LDL-C、FBG、FINS及HOMA-IR呈负相关。多元逐步回归分析显示，FINS、LDL-C、HDL-C及BMI是影响血清BMP-9水平的独立因素（P < 0.05）。逻辑回归分析显示，BMP-9是T2DM合并NAFLD的保护因素，而HOMA-IR是危险因素。
与其他组相比，T2DM + NAFLD组血清BMP-9水平显著降低，且BMP-9是T2DM合并NAFLD的独立危险因素。
