Nadakavukaren M J, Sorensen R H, Tone J N
Cell Tissue Res. 1979 Dec;204(2):293-6. doi: 10.1007/BF00234640.
Gossypol was found to induce sterility in male rats when administered orally. A reduction in the number of spermatozoa in the epididymis from the gossypol-treated rats was observed when compared to the control animals. An examination of the spermatozoa from the treated rats showed the following ultrastructural modifications: disorganization of the mitochondiral sheath and missing cell membrane from the middle piece, broken cell membrane and missing members of both outer fibers and inner microtubules of the principal piece, and broken cell membrane of the sperm head. Serial mating experiments proved that gossypol-treated males were indeed sterile. The results suggest that gossypol at low concentrations is able to affect the motility of spermatozoa, thus contributing to its contraceptive action.
发现口服棉酚可使雄性大鼠不育。与对照动物相比，观察到经棉酚处理的大鼠附睾中精子数量减少。对经处理大鼠的精子进行检查发现有以下超微结构改变：线粒体鞘紊乱，中段细胞膜缺失，主段外纤维和内微管的细胞膜破裂且部分结构缺失，精子头部细胞膜破裂。连续交配实验证明，经棉酚处理的雄性大鼠确实不育。结果表明，低浓度棉酚能够影响精子活力，从而有助于其避孕作用。
