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观察亚精胺对内向整流钾通道 Kir2.2 中钾离子运动的阻断作用。

Seeing spermine blocking of K+ ion movement through inward rectifier Kir2.2 channels.

机构信息

Department of Cell Biology and Physiology, Center for Investigation of Membrane Excitability Diseases, Washington University in. St. Louis, St. Louis, MO, USA.

出版信息

J Gen Physiol. 2023 Feb 6;155(2). doi: 10.1085/jgp.202213144. Epub 2022 Dec 16.

DOI:10.1085/jgp.202213144
PMID:36524992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9764022/
Abstract

Inwardly rectifier potassium (Kir) channels are a major potassium channel sub-class whose function is regulated by ligand-dependent gating and highly voltage-dependent block by polyamines. With molecular dynamics simulations over previously unattainable timescales, Jogini et al. (J. Gen. Physiol. https://doi.org/10.1085/jgp.202213085) provide unprecedented visualization of K+ conduction through open Kir2.2 channels and of the molecular details of channel block by spermine.

摘要

内向整流钾 (Kir) 通道是主要的钾通道亚类之一，其功能受配体依赖性门控和多胺的高度电压依赖性阻断调节。通过以前无法达到的时间尺度的分子动力学模拟，Jogini 等人（J. Gen. Physiol. https://doi.org/10.1085/jgp.202213085）提供了前所未有的可视化，展示了通过开放的 Kir2.2 通道的 K+传导以及 spermine 对通道阻断的分子细节。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d77/9764022/bc95553f8c9a/JGP_202213144_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d77/9764022/bc95553f8c9a/JGP_202213144_Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d77/9764022/bc95553f8c9a/JGP_202213144_Fig1.jpg

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本文引用的文献

1
Gating and modulation of an inward-rectifier potassium channel.内向整流钾通道的门控和调制。
J Gen Physiol. 2023 Feb 6;155(2). doi: 10.1085/jgp.202213085. Epub 2022 Dec 16.
2
Molecular structure of an open human K channel.开放型人钾通道的分子结构。
Proc Natl Acad Sci U S A. 2021 Nov 30;118(48). doi: 10.1073/pnas.2112267118.
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Computational Insights Into Voltage Dependence of Polyamine Block in a Strong Inwardly Rectifying K Channel.对强内向整流钾通道中多胺阻断电压依赖性的计算洞察。
Theranostics. 2024 Jul 8;14(11):4218-4239. doi: 10.7150/thno.95749. eCollection 2024.
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Blockade of TRPV channels by intracellular spermine.细胞内 spermine 对 TRPV 通道的阻断作用。
J Gen Physiol. 2023 May 1;155(5). doi: 10.1085/jgp.202213273. Epub 2023 Mar 13.
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Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels.在哺乳动物内向整流钾 (Kir2.2) 通道中打开和传导的原子基础。
J Gen Physiol. 2020 Jan 6;152(1). doi: 10.1085/jgp.201912422.
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Conduction through a narrow inward-rectifier K channel pore.经内向整流钾通道孔的传导。
J Gen Physiol. 2019 Oct 7;151(10):1231-1246. doi: 10.1085/jgp.201912359. Epub 2019 Sep 11.
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Polyamines and potassium channels: A 25-year romance.多胺与钾通道：25 年的浪漫史。
J Biol Chem. 2018 Nov 30;293(48):18779-18788. doi: 10.1074/jbc.TM118.003344. Epub 2018 Oct 17.
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Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids.大量阴离子磷脂对内向整流型Kir2通道门控的控制的结构基础。
J Gen Physiol. 2016 Sep;148(3):227-37. doi: 10.1085/jgp.201611616. Epub 2016 Aug 15.
8
Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating.具有开放束交叉的 KirBac 钾通道结构表明了通道门控的机制。
Nat Struct Mol Biol. 2012 Jan 8;19(2):158-63. doi: 10.1038/nsmb.2208.
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Nature. 2011 Aug 28;477(7365):495-8. doi: 10.1038/nature10370.
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Locale and chemistry of spermine binding in the archetypal inward rectifier Kir2.1.精胺在典型内向整流钾通道 Kir2.1 中的结合的位置和化学性质。
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