Bodine Sue C
Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA.
Fac Rev. 2022 Nov 11;11:32. doi: 10.12703/r/11-32. eCollection 2022.
Skeletal muscle mass is a very plastic characteristic of skeletal muscle and is regulated by signaling pathways that control the balance between anabolic and catabolic processes. The serine/threonine kinase mechanistic/mammalian target of rapamycin (mTOR) has been shown to be critically important in the regulation of skeletal muscle mass through its regulation of protein synthesis and degradation pathways. In this commentary, recent advances in the understanding of the role of mTORC1 in the regulation of muscle mass under conditions that induce hypertrophy and atrophy will be highlighted.
骨骼肌质量是骨骼肌非常具有可塑性的特征，并且受控制合成代谢和分解代谢过程之间平衡的信号通路调节。丝氨酸/苏氨酸激酶雷帕霉素机制性/哺乳动物靶标（mTOR）已被证明通过调节蛋白质合成和降解途径，在骨骼肌质量的调节中至关重要。在这篇评论中，将重点介绍在诱导肥大和萎缩的条件下，对mTORC1在肌肉质量调节作用理解的最新进展。
